Literature DB >> 11530153

Association between deficiency of mannose-binding lectin and severe infections after chemotherapy.

N A Peterslund, C Koch, J C Jensenius, S Thiel.   

Abstract

The plasma protein mannose-binding lectin (MBL) activates the complement system by binding to carbohydrate structures presented by microorganisms and thus could be an important component of the innate immune defence system. We measured MBL in patients with leukaemia who were scheduled to undergo chemotherapy (ie, a population especially susceptible to infection) and related the results to severity of infection after chemotherapy. We showed a significant association between low concentrations of MBL and serious infections related to chemotherapy (p<0.0001). These results suggest that increasing concentrations of MBL in patients having chemotherapy could reduce susceptibility to infection.

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Year:  2001        PMID： 11530153     DOI： 10.1016/S0140-6736(01)05785-3

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  59 in total

1.  Influence of major surgery on the mannan-binding lectin pathway of innate immunity.

Authors:  H Ytting; I J Christensen; L Basse; J Lykke; S Thiel; J C Jensenius; H J Nielsen
Journal:  Clin Exp Immunol       Date:  2006-05       Impact factor: 4.330

2.  Mannose-binding lectin deficiency provides a genetic basis for the use of SIRS/sepsis definitions in critically ill patients.

Authors:  Joseph A Carcillo
Journal:  Intensive Care Med       Date:  2004-05-06       Impact factor: 17.440

3.  Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli.

Authors:  Alex Smithson; Ana Muñoz; Belen Suarez; Sara Maria Soto; Rafael Perello; Alex Soriano; Jose Antonio Martinez; Jordi Vila; Juan Pablo Horcajada; Jose Mensa; Francisco Lozano
Journal:  Clin Vaccine Immunol       Date:  2007-01-03

4.  Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis.

Authors:  B Fevang; T E Mollnes; A M Holm; T Ueland; L Heggelund; J K Damås; P Aukrust; S S Frøland
Journal:  Clin Exp Immunol       Date:  2005-12       Impact factor: 4.330

5.  Mannose-binding lectin (MBL) as prognostic factor in paediatric oncology patients.

Authors:  F N J Frakking; N Brouwer; K M Dolman; J B M van Woensel; H N Caron; T W Kuijpers; M D van de Wetering
Journal:  Clin Exp Immunol       Date:  2011-04-13       Impact factor: 4.330

Review 6.  Mannan-binding-lectin-associated serine proteases, characteristics and disease associations.

Authors:  Rikke Sørensen; Steffen Thiel; Jens C Jensenius
Journal:  Springer Semin Immunopathol       Date:  2005-11-11

Review 7.  Mannose-binding lectin and maladies of the bowel and liver.

Authors:  Daniel-L Worthley; Peter-G Bardy; David-L Gordon; Charles-G Mullighan
Journal:  World J Gastroenterol       Date:  2006-10-28       Impact factor: 5.742

8.  Mannan-binding lectin in children with Escherichia coli O157:H7 haemmorrhagic colitis and haemolytic uraemic syndrome.

Authors:  F Proulx; E Wagner; B Toledano; H Decaluwe; E G Seidman; G-E Rivard
Journal:  Clin Exp Immunol       Date:  2003-09       Impact factor: 4.330

9.  Heritability estimates for the constitutional levels of the collectins mannan-binding lectin and lung surfactant protein D. A study of unselected like-sexed mono- and dizygotic twins at the age of 6-9 years.

Authors:  Steffen Husby; Anne Maria Herskind; Jens Christian Jensenius; Uffe Holmskov
Journal:  Immunology       Date:  2002-07       Impact factor: 7.397

10.  Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema.

Authors:  Stephen J Chapman; Fredrik O Vannberg; Chiea C Khor; Anna Rautanen; Nicholas A Maskell; Christopher W H Davies; Catrin E Moore; Nicholas P Day; Derrick W Crook; Robert J O Davies; Adrian V S Hill
Journal:  BMC Med Genet       Date:  2010-01-15       Impact factor: 2.103
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