| Literature DB >> 11529764 |
S B Singh1, D L Zink, J M Liesch, A W Dombrowski, S J Darkin-Rattray, D M Schmatz, M A Goetz.
Abstract
[structure: see text]. Isolation and structure elucidation of two novel cyclic tetrapeptides that show a variety of potent antiprotozoal activities by reversibly inhibiting HDAC have been reported. These are the new members of a unique family of cyclic tetrapeptides that do not require the electrophilic alpha-epoxyketone moiety of HC-toxin, trapoxin A, or chlamydocin for their potent activities against HDAC and the malarial parasite.Entities:
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Year: 2001 PMID： 11529764 DOI： 10.1021/ol016240g
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005