Literature DB >> 11529

Discriminable effects of benzodiazepines.

D A Overton.   

Abstract

In a shock-escape T-maze task, rats rapidly discriminated diazepam, flurazepam and chloridazepoxide from no drug. The discriminable effects of these benzodiazepines were not completely interchangeable with those of barbiturate anesthetics. The dose-response curve for diazepam asymptoted over the range 15 to 100 mg/kg, ip whereas dose-response curves for flurazepam and chloridazepoxide were more linear.

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Year:  1976        PMID: 11529

Source DB:  PubMed          Journal:  Psychopharmacol Commun        ISSN: 0098-616X


  10 in total

1.  A comparison of diazepam stimuli in aged and adult rats.

Authors:  C L Amrick; D A Bennett
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

2.  Comparison of the degree of discriminability of various drugs using the T-maze drug discrimination paradigm.

Authors:  D A Overton
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

3.  Effects of several benzodiazepines, alone and in combination with flumazenil, in rhesus monkeys trained to discriminate pentobarbital from saline.

Authors:  W L Woolverton; M A Nader
Journal:  Psychopharmacology (Berl)       Date:  1995-12       Impact factor: 4.530

4.  Effects of chlordiazepoxide training dose on the mixed agonist-antagonist properties of benzodiazepine receptor antagonist Ro 15-1788, in a drug discrimination procedure.

Authors:  J De Vry; J L Slangen
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

5.  Differential generalization to pentobarbital in rats trained to discriminate lorazepam, chlordiazepoxide, diazepam, or triazolam.

Authors:  N A Ator; R R Griffiths
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

6.  Midazolam cue in rats: generalization tests with anxiolytic and other drugs.

Authors:  H S Garcha; I C Rose; I P Stolerman
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

7.  Effect of diazepam and chlorpromazine on memory functions in man.

Authors:  R Liljequist; M Linnoila; M J Mattila
Journal:  Eur J Clin Pharmacol       Date:  1978-07-30       Impact factor: 2.953

8.  Discriminative stimulus properties of a new anxiolytic, DN-2327, in rats.

Authors:  T Wada; N Fukuda
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

9.  Stimulus properties of benzodiazepines: correlations with binding affinities, therapeutic potency, and structure activity relationships (SAR).

Authors:  R Young; R A Glennon
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

10.  The discriminative stimulus properties of zolpidem, a novel imidazopyridine hypnotic.

Authors:  D J Sanger; B Zivkovic
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

  10 in total

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