OBJECTIVES: The aim of this study was to determine the time course of autonomic nervous system activity preceding ambulatory ischemic events. BACKGROUND: Vagal withdrawal can produce myocardial ischemia and may be involved in the genesis of ambulatory ischemic events. We analyzed trajectories of heart rate variability (HRV) 1 h before and after ischemic events, and we examined the role of exercise and mental stress in preischemic autonomic changes. METHODS: Male patients with stable coronary artery disease (n = 19; 62.1 +/- 9.3 years) underwent 48-h ambulatory electrocardiographic monitoring. Frequency domain HRV measures were assessed for 60 min before and after each of 68 ischemic events and during nonischemic heart rate-matched control periods. RESULTS: High-frequency HRV decreased from -60, -20 to -10 min before ischemic events (4.8 +/- 1.3; 4.6 +/- 1.3; 4.4 +/- 1.2 ln [ms(2)], respectively; p = 0.04) and further from -4, -2 min, until ischemia (4.4 +/- 1.3; 4.1 +/- 1.3; 3.7 +/- 1.2 ln [ms(2)]; p's < 0.01). Low frequency HRV decreases started at -4 min (p < 0.05). Ischemic events occurring at high mental activities were preceded by depressed high frequency HRV levels compared with events at low mental activity (p = 0.038 at -4 min, p = 0.045 at -2 min), whereas the effects of mental activities were not observed during nonischemic control periods. Heart rate variability measures remained significantly decreased for 20 min after recovery of ST-segment depression when events were triggered by high activity levels. CONCLUSIONS: Autonomic changes consistent with vagal withdrawal can act as a precipitating factor for daily life ischemia, particularly in episodes triggered by mental activities.
OBJECTIVES: The aim of this study was to determine the time course of autonomic nervous system activity preceding ambulatory ischemic events. BACKGROUND: Vagal withdrawal can produce myocardial ischemia and may be involved in the genesis of ambulatory ischemic events. We analyzed trajectories of heart rate variability (HRV) 1 h before and after ischemic events, and we examined the role of exercise and mental stress in preischemic autonomic changes. METHODS: Male patients with stable coronary artery disease (n = 19; 62.1 +/- 9.3 years) underwent 48-h ambulatory electrocardiographic monitoring. Frequency domain HRV measures were assessed for 60 min before and after each of 68 ischemic events and during nonischemic heart rate-matched control periods. RESULTS: High-frequency HRV decreased from -60, -20 to -10 min before ischemic events (4.8 +/- 1.3; 4.6 +/- 1.3; 4.4 +/- 1.2 ln [ms(2)], respectively; p = 0.04) and further from -4, -2 min, until ischemia (4.4 +/- 1.3; 4.1 +/- 1.3; 3.7 +/- 1.2 ln [ms(2)]; p's < 0.01). Low frequency HRV decreases started at -4 min (p < 0.05). Ischemic events occurring at high mental activities were preceded by depressed high frequency HRV levels compared with events at low mental activity (p = 0.038 at -4 min, p = 0.045 at -2 min), whereas the effects of mental activities were not observed during nonischemic control periods. Heart rate variability measures remained significantly decreased for 20 min after recovery of ST-segment depression when events were triggered by high activity levels. CONCLUSIONS: Autonomic changes consistent with vagal withdrawal can act as a precipitating factor for daily life ischemia, particularly in episodes triggered by mental activities.
Authors: Willem J Kop; Stephen J Synowski; Miranda E Newell; Louis A Schmidt; Shari R Waldstein; Nathan A Fox Journal: Biol Psychol Date: 2010-12-21 Impact factor: 3.251
Authors: Anthony S Leicht; Andreas D Flouris; Antonia Kaltsatou; Andrew J Seely; Christophe L Herry; Heather E Wright Beatty; Glen P Kenny Journal: Temperature (Austin) Date: 2018-03-15
Authors: Iny Jhun; Jina Kim; Bennet Cho; Diane R Gold; Joel Schwartz; Brent A Coull; Antonella Zanobetti; Mary B Rice; Murray A Mittleman; Eric Garshick; Pantel Vokonas; Marie-Abele Bind; Elissa H Wilker; Francesca Dominici; Helen Suh; Petros Koutrakis Journal: J Air Waste Manag Assoc Date: 2019-08 Impact factor: 2.235
Authors: Preben Bjerregaard; Amr El-Shafei; Susan L Kotar; Arthur J Labovitz Journal: Ann Noninvasive Electrocardiol Date: 2003-07 Impact factor: 1.468
Authors: Alexander Haensel; Paul J Mills; Richard A Nelesen; Michael G Ziegler; Joel E Dimsdale Journal: Psychoneuroendocrinology Date: 2008-09-25 Impact factor: 4.905
Authors: Claudia Lerma; Niels Wessel; Alexander Schirdewan; Jürgen Kurths; Leon Glass Journal: Med Biol Eng Comput Date: 2008-03-15 Impact factor: 2.602
Authors: Jeroen J de Hartog; Timo Lanki; Kirsi L Timonen; Gerard Hoek; Nicole A H Janssen; Angela Ibald-Mulli; Annette Peters; Joachim Heinrich; Tuula H Tarkiainen; Rene van Grieken; Joop H van Wijnen; Bert Brunekreef; Juha Pekkanen Journal: Environ Health Perspect Date: 2008-08-25 Impact factor: 9.031
Authors: Antonella Zanobetti; Diane R Gold; Peter H Stone; Helen H Suh; Joel Schwartz; Brent A Coull; Frank E Speizer Journal: Environ Health Perspect Date: 2009-11-18 Impact factor: 9.031