Literature DB >> 11526217

Modulation of HIV-like particle assembly in vitro by inositol phosphates.

S Campbell1, R J Fisher, E M Towler, S Fox, H J Issaq, T Wolfe, L R Phillips, A Rein.   

Abstract

HIV-1 Gag protein assembles into 100- to 120-nm diameter particles in mammalian cells. Recombinant HIV-1 Gag protein assembles in a fully defined system in vitro into particles that are only 25-30 nm in diameter and that differ significantly in other respects from authentic particles. However, particles with the size and other properties of authentic virions were obtained in vitro by addition of inositol phosphates or phosphatidylinsitol phosphates to the assembly system. Thus, the interactions between HIV-1 Gag protein molecules are altered by binding of inositol derivatives; this binding is apparently essential for normal HIV-1 particle assembly. This requirement is not seen in a deleted Gag protein lacking residues 16-99 within the matrix domain.

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Year:  2001        PMID： 11526217      PMCID： PMC58567          DOI： 10.1073/pnas.191224698

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  RNA is a structural element in retrovirus particles.

Authors:  D Muriaux; J Mirro; D Harvin; A Rein
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-24       Impact factor: 11.205

2.  A conformational switch controlling HIV-1 morphogenesis.

Authors:  I Gross; H Hohenberg; T Wilk; K Wiegers; M Grättinger; B Müller; S Fuller; H G Kräusslich
Journal:  EMBO J       Date:  2000-01-04       Impact factor: 11.598

3.  Preparation and use of nuclease-treated rabbit reticulocyte lysates for the translation of eukaryotic messenger RNA.

Authors:  R J Jackson; T Hunt
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

4.  G-protein signaling through tubby proteins.

Authors:  S Santagata; T J Boggon; C L Baird; C A Gomez; J Zhao; W S Shan; D G Myszka; L Shapiro
Journal:  Science       Date:  2001-05-24       Impact factor: 47.728

5.  Mass changes in inositol tetrakis- and pentakisphosphate isomers induced by chemotactic peptide stimulation in HL-60 cells.

Authors:  D Pittet; W Schlegel; D P Lew; A Monod; G W Mayr
Journal:  J Biol Chem       Date:  1989-11-05       Impact factor: 5.157

6.  In vitro assembly properties of human immunodeficiency virus type 1 Gag protein lacking the p6 domain.

Authors:  S Campbell; A Rein
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

7.  Mass changes of inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate during cell cycle progression in rat thymocytes.

Authors:  A H Guse; E Greiner; F Emmrich; K Brand
Journal:  J Biol Chem       Date:  1993-04-05       Impact factor: 5.157

8.  Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.

Authors:  T Itoh; S Koshiba; T Kigawa; A Kikuchi; S Yokoyama; T Takenawa
Journal:  Science       Date:  2001-02-09       Impact factor: 47.728

9.  Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes.

Authors:  M G Ford; B M Pearse; M K Higgins; Y Vallis; D J Owen; A Gibson; C R Hopkins; P R Evans; H T McMahon
Journal:  Science       Date:  2001-02-09       Impact factor: 47.728

10.  The interconversion of inositol 1,3,4,5,6-pentakisphosphate and inositol tetrakisphosphates in AR4-2J cells.

Authors:  K G Oliver; J W Putney; J F Obie; S B Shears
Journal:  J Biol Chem       Date:  1992-10-25       Impact factor: 5.157
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  113 in total

1.  Nucleic acid-independent retrovirus assembly can be driven by dimerization.

Authors:  Marc C Johnson; Heather M Scobie; Yu May Ma; Volker M Vogt
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

2.  Exploring the paths of (virus) assembly.

Authors:  Paul Moisant; Henry Neeman; Adam Zlotnick
Journal:  Biophys J       Date:  2010-09-08       Impact factor: 4.033

3.  Conserved and variable features of Gag structure and arrangement in immature retrovirus particles.

Authors:  Alex de Marco; Norman E Davey; Pavel Ulbrich; Judith M Phillips; Vanda Lux; James D Riches; Tibor Fuzik; Tomas Ruml; Hans-Georg Kräusslich; Volker M Vogt; John A G Briggs
Journal:  J Virol       Date:  2010-09-01       Impact factor: 5.103

4.  Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome.

Authors:  Cristina Gherghe; Tania Lombo; Christopher W Leonard; Siddhartha A K Datta; Julian W Bess; Robert J Gorelick; Alan Rein; Kevin M Weeks
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-25       Impact factor: 11.205

Review 5.  Nucleic acid chaperone activity of retroviral Gag proteins.

Authors:  Alan Rein
Journal:  RNA Biol       Date:  2010-11-01       Impact factor: 4.652

6.  Dimerization of the SP1 Region of HIV-1 Gag Induces a Helical Conformation and Association into Helical Bundles: Implications for Particle Assembly.

Authors:  Siddhartha A K Datta; Patrick K Clark; Lixin Fan; Buyong Ma; Demetria P Harvin; Raymond C Sowder; Ruth Nussinov; Yun-Xing Wang; Alan Rein
Journal:  J Virol       Date:  2015-12-04       Impact factor: 5.103

7.  scyllo-inositol pentakisphosphate as an analogue of myo-inositol 1,3,4,5,6-pentakisphosphate: chemical synthesis, physicochemistry and biological applications.

Authors:  Andrew M Riley; Melanie Trusselle; Paul Kuad; Michal Borkovec; Jaiesoon Cho; Jae H Choi; Xun Qian; Stephen B Shears; Bernard Spiess; Barry V L Potter
Journal:  Chembiochem       Date:  2006-07       Impact factor: 3.164

8.  HIV-1 Gag: flipped out for PI(4,5)P(2).

Authors:  Eric O Freed
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-17       Impact factor: 11.205

9.  Conformation of the HIV-1 Gag protein in solution.

Authors:  Siddhartha A K Datta; Joseph E Curtis; William Ratcliff; Patrick K Clark; Rachael M Crist; Jacob Lebowitz; Susan Krueger; Alan Rein
Journal:  J Mol Biol       Date:  2006-10-26       Impact factor: 5.469

10.  Assembly properties of human immunodeficiency virus type 1 Gag-leucine zipper chimeras: implications for retrovirus assembly.

Authors:  Rachael M Crist; Siddhartha A K Datta; Andrew G Stephen; Ferri Soheilian; Jane Mirro; Robert J Fisher; Kunio Nagashima; Alan Rein
Journal:  J Virol       Date:  2008-12-10       Impact factor: 5.103
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