Literature DB >> 11523012

Viral eukaryogenesis: was the ancestor of the nucleus a complex DNA virus?

P J Bell.   

Abstract

In the theory of viral eukaryogenesis I propose here, the eukaryotic nucleus evolved from a complex DNA virus. It is proposed that the virus established a persistent presence in the cytoplasm of a methanogenic mycoplasma and evolved into the eukaryotic nucleus by acquiring a set of essential genes from the host genome and eventually usurping its role. It is proposed that several characteristic features of the eukaryotic nucleus derive from its viral ancestry. These include mRNA capping, linear chromosomes, and separation of transcription from translation. In the model, phagocytosis and other membrane fusion-based processes are derived from viral membrane fusion processes and evolved in concert with the nucleus. The coevolution of phagocytosis and the nucleus rendered much of the host archaeal genome redundant since the protoeukaryote could obtain raw materials and energy by engulfing bacterial syntrophs/prey. This redundancy allowed loss of the archaeal chromosome, generating an organism with eukaryotic features. The evolution of phagocytosis allowed the eukaryotes to be the first organisms to occupy the niche of predator.

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Year:  2001        PMID: 11523012     DOI: 10.1007/s002390010215

Source DB:  PubMed          Journal:  J Mol Evol        ISSN: 0022-2844            Impact factor:   2.395


  54 in total

1.  Structural studies of E73 from a hyperthermophilic archaeal virus identify the "RH3" domain, an elaborated ribbon-helix-helix motif involved in DNA recognition.

Authors:  Casey Schlenker; Anupam Goel; Brian P Tripet; Smita Menon; Taylor Willi; Mensur Dlakić; Mark J Young; C Martin Lawrence; Valérie Copié
Journal:  Biochemistry       Date:  2012-03-22       Impact factor: 3.162

2.  Comparisons of two large phaeoviral genomes and evolutionary implications.

Authors:  Nicolas Delaroque; Wilhelm Boland; Dieter Gerhard Müller; Rolf Knippers
Journal:  J Mol Evol       Date:  2003-12       Impact factor: 2.395

3.  Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: a hypothesis for the origin of cellular domain.

Authors:  Patrick Forterre
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-27       Impact factor: 11.205

4.  Not so simple after all. A renaissance of research into prokaryotic evolution and cell structure.

Authors:  Philip Hunter
Journal:  EMBO Rep       Date:  2008-03       Impact factor: 8.807

5.  Horizontal gene transfer of an entire metabolic pathway between a eukaryotic alga and its DNA virus.

Authors:  Adam Monier; António Pagarete; Colomban de Vargas; Michael J Allen; Betsy Read; Jean-Michel Claverie; Hiroyuki Ogata
Journal:  Genome Res       Date:  2009-05-18       Impact factor: 9.043

Review 6.  Structural and functional studies of archaeal viruses.

Authors:  C Martin Lawrence; Smita Menon; Brian J Eilers; Brian Bothner; Reza Khayat; Trevor Douglas; Mark J Young
Journal:  J Biol Chem       Date:  2009-01-21       Impact factor: 5.157

7.  Viral genomes are part of the phylogenetic tree of life.

Authors:  Ethan B Ludmir; Lynn W Enquist
Journal:  Nat Rev Microbiol       Date:  2009-08       Impact factor: 60.633

8.  Plant communication from biosemiotic perspective: differences in abiotic and biotic signal perception determine content arrangement of response behavior. Context determines meaning of meta-, inter- and intraorganismic plant signaling.

Authors:  Günther Witzany
Journal:  Plant Signal Behav       Date:  2006-07

9.  Origin of eukaryotic cells as a symbiosis of parasitic alpha-proteobacteria in the periplasm of two-membrane-bounded sexual pre-karyotes.

Authors:  Matej Vesteg; Juraj Krajcovic
Journal:  Commun Integr Biol       Date:  2008

10.  Steps towards the formation of a protocell: the possible role of short peptides.

Authors:  Maya Fishkis
Journal:  Orig Life Evol Biosph       Date:  2007-09-14       Impact factor: 1.950

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