Literature DB >> 11522941

Reduced IP3 sensitivity of IP3 receptor in Purkinje neurons.

A Fujiwara1, K Hirose, T Yamazawa, M Iino.   

Abstract

The inositol 1,4,5-trisphosphate receptor (IP3R) is highly expressed in Purkinje neurons (PNs) and is thought to be essential for the induction of long-term depression at parallel-fiber-PN synapses. Here, by imaging the fluorescence intensity of the low-affinity Ca2+ indicator inside the Ca2+ stores in the permeabilized single PNs, we analyzed the kinetics of Ca2+ release via the IP3R in controlled cytoplasmic environments. The rate of Ca2+ release is dependent on the IP3 concentration with an EC50 of 25.8 microM, which is > 20-fold greater than that of the IP3R in the isolated preparations or in peripheral cells. This property would be advantageous in inducing the release of Ca2+ in a localized space adjacent to the site of synaptic inputs.

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Year:  2001        PMID： 11522941     DOI： 10.1097/00001756-200108280-00012

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  13 in total

1.  Activation of protein kinase C in sensory neurons accelerates Ca2+ uptake into the endoplasmic reticulum.

Authors:  Yuriy M Usachev; Anthony J Marsh; Tanner M Johanns; Michelle M Lemke; Stanley A Thayer
Journal:  J Neurosci       Date:  2006-01-04       Impact factor: 6.167

2.  Spontaneously active and InsP3-activated ion channels in cell nuclei from rat cerebellar Purkinje and granule neurones.

Authors:  Sergey M Marchenko; Victor V Yarotskyy; Tatiana N Kovalenko; Platon G Kostyuk; Roger C Thomas
Journal:  J Physiol       Date:  2005-03-17       Impact factor: 5.182

3.  Modeling and analysis of calcium signaling events leading to long-term depression in cerebellar Purkinje cells.

Authors:  Nicholas Hernjak; Boris M Slepchenko; Kathleen Fernald; Charles C Fink; Dale Fortin; Ion I Moraru; James Watras; Leslie M Loew
Journal:  Biophys J       Date:  2005-09-16       Impact factor: 4.033

4.  Kinetic, pharmacological and activity-dependent separation of two Ca2+ signalling pathways mediated by type 1 metabotropic glutamate receptors in rat Purkinje neurones.

Authors:  Marco Canepari; David Ogden
Journal:  J Physiol       Date:  2006-02-23       Impact factor: 5.182

Review 5.  Inositol 1,4,5-trisphosphate receptor-mediated calcium release in Purkinje cells: from molecular mechanism to behavior.

Authors:  Jun-Ichi Goto; Katsuhiko Mikoshiba
Journal:  Cerebellum       Date:  2011-12       Impact factor: 3.847

Review 6.  mGluR1/TRPC3-mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons.

Authors:  Jana Hartmann; Horst A Henning; Arthur Konnerth
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-04-01       Impact factor: 10.005

7.  Inositol 1,4,5-trisphosphate-dependent Ca2+ threshold dynamics detect spike timing in cerebellar Purkinje cells.

Authors:  Tomokazu Doi; Shinya Kuroda; Takayuki Michikawa; Mitsuo Kawato
Journal:  J Neurosci       Date:  2005-01-26       Impact factor: 6.167

8.  Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.

Authors:  Nael Nadif Kasri; Anthony M Holmes; Geert Bultynck; Jan B Parys; Martin D Bootman; Katja Rietdorf; Ludwig Missiaen; Fraser McDonald; Humbert De Smedt; Stuart J Conway; Andrew B Holmes; Michael J Berridge; H Llewelyn Roderick
Journal:  EMBO J       Date:  2003-12-18       Impact factor: 11.598

9.  Studying isoform-specific inositol 1,4,5-trisphosphate receptor function and regulation.

Authors:  Matthew J Betzenhauser; Larry E Wagner; Jong Hak Won; David I Yule
Journal:  Methods       Date:  2008-10-16       Impact factor: 3.608

10.  IP(3) mobilization and diffusion determine the timing window of Ca(2+) release by synaptic stimulation and a spike in rat CA1 pyramidal cells.

Authors:  Satoshi Manita; William N Ross
Journal:  Hippocampus       Date:  2010-04       Impact factor: 3.899
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