| Literature DB >> 1151990 |
J A Vida, C M Samour, M H O'Dea, J F Reinhard.
Abstract
Several 1,3-disubstituted and 1-substituted derivatives of 5-propionoxy-5-(1-phenylethyl)barbituric acid were synthesized and evaluated for analgesic activity. Three of these compounds, 1,3-bis(methoxymethyl)-5-propionoxy-5-(1-phenylethyl)barbituric acid (2), 1,3-dimethyl-5-propionoxy-5-(1-phenylethyl)barbituric acid (7), and 1-methyl-5-propionoxy-5-(1-phenylethyl)barbituric acid (10), exhibited better oral activity than codeine sulfate.Entities:
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Year: 1975 PMID： 1151990 DOI： 10.1021/jm00241a010
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446