| Literature DB >> 1151965 |
C Hansch, A Vittoria, C Silipo, P Y Jow.
Abstract
Partition coefficients of 32 gaseous anesthetics in the octanol-water system have been determined. It is shown that relative anesthetic potency depends on hydrophobicity of the anesthetic (as defined by log P) and on a polar factor. The presence of a polar hydrogen in the anesthetic greatly increases potency. A quantitative structure-activity relationship is formulated based on these two factors.Entities:
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Year: 1975 PMID： 1151965 DOI： 10.1021/jm00240a002
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446