Literature DB >> 11514167

The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.

J I Levin1, J Chen, M Du, M Hogan, S Kincaid, F C Nelson, A M Venkatesan, T Wehr, A Zask, J DiJoseph, L M Killar, S Skala, A Sung, M Sharr, C Roth, G Jin, R Cowling, K M Mohler, R A Black, C J March, J S Skotnicki.   

Abstract

A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, MMP-13, and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and TACE were identified, including the potent, orally active MMP-13 inhibitor 4p.

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Year:  2001        PMID： 11514167     DOI： 10.1016/s0960-894x(01)00419-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  22 in total

1.  Anthranilate derivatives as TACE inhibitors: docking based CoMFA and CoMSIA analyses.

Authors:  Malkeet Singh Bahia; Shravan Kumar Gunda; Shwetha Reddy Gade; Saikh Mahmood; Ravikumar Muttineni; Om Silakari
Journal:  J Mol Model       Date:  2010-03-28       Impact factor: 1.810

2.  Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy.

Authors:  Khalil Miloudi; François Binet; Ariel Wilson; Agustin Cerani; Malika Oubaha; Catherine Menard; Sullivan Henriques; Gaelle Mawambo; Agnieszka Dejda; Phuong Trang Nguyen; Flavio A Rezende; Steve Bourgault; Timothy E Kennedy; Przemyslaw Sapieha
Journal:  J Clin Invest       Date:  2016-07-11       Impact factor: 14.808

Review 3.  Effects of Ethanol on Brain Extracellular Matrix: Implications for Alcohol Use Disorder.

Authors:  Amy W Lasek
Journal:  Alcohol Clin Exp Res       Date:  2016-09-01       Impact factor: 3.455

4.  Matrix metalloproteinase (MMP)-9 induced by Wnt signaling increases the proliferation and migration of embryonic neural stem cells at low O2 levels.

Authors:  Christopher A Ingraham; Gabriel C Park; Helen P Makarenkova; Kathryn L Crossin
Journal:  J Biol Chem       Date:  2011-04-01       Impact factor: 5.157

5.  The role of matrix metalloproteinase-9 in negative reinforcement learning and plasticity in alcohol dependence.

Authors:  Bok Soon Go; Sunil Sirohi; Brendan M Walker
Journal:  Addict Biol       Date:  2019-01-16       Impact factor: 4.280

6.  Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.

Authors:  Wen Hao Neo; Christopher A G Booth; Emanuele Azzoni; Lijun Chi; Paul Delgado-Olguín; Marella F T R de Bruijn; Sten Eirik W Jacobsen; Adam J Mead
Journal:  Blood       Date:  2018-03-19       Impact factor: 22.113

7.  Differential androgen deprivation therapies with anti-androgens casodex/bicalutamide or MDV3100/Enzalutamide versus anti-androgen receptor ASC-J9(R) Lead to promotion versus suppression of prostate cancer metastasis.

Authors:  Tzu-Hua Lin; Soo Ok Lee; Yuanjie Niu; Defeng Xu; Liang Liang; Lei Li; Shauh-Der Yeh; Naohiro Fujimoto; Shuyuan Yeh; Chawnshang Chang
Journal:  J Biol Chem       Date:  2013-05-16       Impact factor: 5.157

8.  The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation.

Authors:  Takaomi Okawa; Carmen Z Michaylira; Jiri Kalabis; Douglas B Stairs; Hiroshi Nakagawa; Claudia D Andl; Cameron N Johnstone; Andres J Klein-Szanto; Wafik S El-Deiry; Edna Cukierman; Meenhard Herlyn; Anil K Rustgi
Journal:  Genes Dev       Date:  2007-11-01       Impact factor: 11.361

9.  Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.

Authors:  Lata T Gooljarsingh; Ami Lakdawala; Frank Coppo; Lusong Luo; Gregg B Fields; Peter J Tummino; Richard R Gontarek
Journal:  Protein Sci       Date:  2007-11-27       Impact factor: 6.725

10.  A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.

Authors:  Amit Gaggar; Patricia L Jackson; Brett D Noerager; Philip J O'Reilly; D Brent McQuaid; Steven M Rowe; J P Clancy; J Edwin Blalock
Journal:  J Immunol       Date:  2008-04-15       Impact factor: 5.422
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