OBJECTIVE: We examined serum cystatin C concentrations in patients to explore the possible clinical application of cystatin C as a marker of disease severity in cases of chronic liver diseases. METHODS: Serum cystatin C concentrations were determined by an enzyme-linked immunosorbent assay kit in 103 patients with various chronic liver diseases and compared with concentrations in healthy control volunteers. RESULTS: The mean cystatin C concentration was 0.68 +/- 0.03 mg/l in chronic hepatitis patients, 1.13 +/- 0.09 mg/l in liver cirrhosis patients and 1.16 +/- 0.10 mg/l in hepatocellular carcinoma patients, all significantly higher than concentrations in the control volunteers (P < 0.0001). Significant correlations were observed between cystatin C concentrations and total bilirubin levels, albumin levels, platelet levels, type IV collagen levels and hyaluronic acid levels. Serum cystatin C concentrations correlated well with histological stages despite the lack of correlation with histological grades. CONCLUSION: Our results show that serum cystatin C increases with the progression of chronic liver disease and that it is a potential marker for liver fibrosis.
OBJECTIVE: We examined serum cystatin C concentrations in patients to explore the possible clinical application of cystatin C as a marker of disease severity in cases of chronic liver diseases. METHODS: Serum cystatin C concentrations were determined by an enzyme-linked immunosorbent assay kit in 103 patients with various chronic liver diseases and compared with concentrations in healthy control volunteers. RESULTS: The mean cystatin C concentration was 0.68 +/- 0.03 mg/l in chronic hepatitispatients, 1.13 +/- 0.09 mg/l in liver cirrhosispatients and 1.16 +/- 0.10 mg/l in hepatocellular carcinomapatients, all significantly higher than concentrations in the control volunteers (P < 0.0001). Significant correlations were observed between cystatin C concentrations and total bilirubin levels, albumin levels, platelet levels, type IV collagen levels and hyaluronic acid levels. Serum cystatin C concentrations correlated well with histological stages despite the lack of correlation with histological grades. CONCLUSION: Our results show that serum cystatin C increases with the progression of chronic liver disease and that it is a potential marker for liver fibrosis.
Authors: Elias Xirouchakis; Laura Marelli; Evangelos Cholongitas; Pinelopi Manousou; Vincenza Calvaruso; Maria Pleguezuelo; Gian Piero Guerrini; Sergio Maimone; Andrew Kerry; Mark Hajjawi; Devaki Nair; Michael Thomas; David Patch; Andrew Kenneth Burroughs Journal: Clin J Am Soc Nephrol Date: 2010-09-09 Impact factor: 8.237
Authors: Nisha I Parikh; Shih-Jen Hwang; Qiong Yang; Martin G Larson; Chao-Yu Guo; Sander J Robins; Patrice Sutherland; Emelia J Benjamin; Daniel Levy; Caroline S Fox Journal: Am J Cardiol Date: 2008-09-12 Impact factor: 2.778
Authors: Axel M Gressner; Birgit Lahme; Steffen K Meurer; Olav Gressner; Ralf Weiskirchen Journal: World J Gastroenterol Date: 2006-02-07 Impact factor: 5.742