Literature DB >> 11504867

Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair system.

C T Lin1, Y L Lyu, H Xiao, W H Lin, J Whang-Peng.   

Abstract

Mismatch repair (MMR)-deficient cells are shown to produce >15-fold more methotrexate-resistant colonies than MMR normal cells. The increased resistance to methotrexate is primarily due to gene amplification since all the resistant clones contain double-minute chromosomes and increased copy numbers of the DHFR gene. In addition, integration of linearized or retroviral DNAs into chromosomes is also significantly elevated in MMR-deficient cells. These results suggest that in addition to microsatellite instability and homeologous recombination, MMR is also involved in suppression of other genome instabilities such as gene amplification and chromosomal DNA integration.

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Year:  2001        PMID： 11504867      PMCID： PMC55855          DOI： 10.1093/nar/29.16.3304

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  53 in total

Review 1.  DNA mismatch repair and genetic instability.

Authors:  B D Harfe; S Jinks-Robertson
Journal:  Annu Rev Genet       Date:  2000       Impact factor: 16.830

2.  Inverted repeats as genetic elements for promoting DNA inverted duplication: implications in gene amplification.

Authors:  C T Lin; W H Lin; Y L Lyu; J Whang-Peng
Journal:  Nucleic Acids Res       Date:  2001-09-01       Impact factor: 16.971

3.  Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

Authors:  D B Roth; J H Wilson
Journal:  Mol Cell Biol       Date:  1986-12       Impact factor: 4.272

Review 4.  DNA double-strand breaks: signaling, repair and the cancer connection.

Authors:  K K Khanna; S P Jackson
Journal:  Nat Genet       Date:  2001-03       Impact factor: 38.330

5.  Studies on the developmentally regulated expression and amplification of insect chorion genes.

Authors:  F C Kafatos; S A Mitsialis; N Spoerel; B Mariani; J R Lingappa; C Delidakis
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1985

6.  Large inverted duplications are associated with gene amplification.

Authors:  M Ford; M Fried
Journal:  Cell       Date:  1986-05-09       Impact factor: 41.582

7.  Gene amplification in a single cell cycle in Chinese hamster ovary cells.

Authors:  B D Mariani; R T Schimke
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157

Review 8.  DNA double strand break repair in mammalian cells.

Authors:  P Karran
Journal:  Curr Opin Genet Dev       Date:  2000-04       Impact factor: 5.578

9.  High-frequency illegitimate integration of transfected DNA at preintegrated target sites in a mammalian genome.

Authors:  R V Merrihew; K Marburger; S L Pennington; D B Roth; J H Wilson
Journal:  Mol Cell Biol       Date:  1996-01       Impact factor: 4.272

10.  Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: possible mechanisms and relevance to tumor promotion.

Authors:  A Varshavsky
Journal:  Cell       Date:  1981-08       Impact factor: 41.582
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  9 in total

1.  High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.

Authors:  S Chen; S H Bigner; P Modrich
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

2.  Autophagy suppresses tumor progression by limiting chromosomal instability.

Authors:  Robin Mathew; Sameera Kongara; Brian Beaudoin; Cristina M Karp; Kevin Bray; Kurt Degenhardt; Guanghua Chen; Shengkan Jin; Eileen White
Journal:  Genes Dev       Date:  2007-05-17       Impact factor: 11.361

3.  Assessing metabolic stress and autophagy status in epithelial tumors.

Authors:  Robin Mathew; Vassiliki Karantza-Wadsworth; Eileen White
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600

4.  Human MutL-complexes monitor homologous recombination independently of mismatch repair.

Authors:  Simone Yasmin Siehler; Michael Schrauder; Ulrike Gerischer; Sharon Cantor; Giancarlo Marra; Lisa Wiesmüller
Journal:  DNA Repair (Amst)       Date:  2008-11-29

5.  Met promotes the formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts.

Authors:  Yantao Bao; Jia Liu; Jia You; Di Wu; Yang Yu; Chang Liu; Lei Wang; Fei Wang; Lu Xu; Liqun Wang; Nan Wang; Xing Tian; Falin Wang; Hongbin Liang; Yating Gao; Xiaobo Cui; Guohua Ji; Jing Bai; Jingcui Yu; Xiangning Meng; Yan Jin; Wenjing Sun; Xin-Yuan Guan; Chunyu Zhang; Songbin Fu
Journal:  Oncotarget       Date:  2016-08-30

Review 6.  Long non-coding RNAs in anti-cancer drug resistance.

Authors:  Qin-Nan Chen; Chen-Chen Wei; Zhao-Xia Wang; Ming Sun
Journal:  Oncotarget       Date:  2017-01-03

7.  Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2.

Authors:  Sarah A Martin; Afshan McCarthy; Louise J Barber; Darren J Burgess; Suzanne Parry; Christopher J Lord; Alan Ashworth
Journal:  EMBO Mol Med       Date:  2009-09       Impact factor: 12.137

8.  Repression of mutagenesis by Rad51D-mediated homologous recombination.

Authors:  John M Hinz; Robert S Tebbs; Paul F Wilson; Peter B Nham; Edmund P Salazar; Hatsumi Nagasawa; Salustra S Urbin; Joel S Bedford; Larry H Thompson
Journal:  Nucleic Acids Res       Date:  2006-03-06       Impact factor: 16.971

9.  Downregulation of GSK3β by miR-544a to maintain self-renewal ability of lung caner stem cells.

Authors:  Xiao-Mei Mo; Hua-Hui Li; Ming Liu; Yan-Tuan Li
Journal:  Oncol Lett       Date:  2014-07-28       Impact factor: 2.967
  9 in total

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