Literature DB >> 11501469

OR-1--a mixture of esters of glyceric acid produced by Penicillium funiculosum and its antitrypsin activity.

K Lesová1, M Sturdíková, B Proksa, M Pigos, T Liptaj.   

Abstract

A mixture of related metabolites (denoted OR-1) was isolated from the fermentation broth of Penicillium funiculosum together with mitorubrinic acid. Structurally OR-1 is glyceric acid esterified with C14-C18 fatty acids. Steady-state studies revealed that OR-1 behaved like an uncompetitive trypsin inhibitor with Ki 17.6 mumol/L.

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Year:  2001        PMID： 11501469     DOI： 10.1007/bf02825878

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  9 in total

1.  TAN-931, a novel nonsteroidal aromatase inhibitor produced by Penicillium funiculosum No. 8974. I. Taxonomy, fermentation, isolation,characterization and biological activities.

Authors:  T Ishii; T Hida; T Ishimaru; S Iinuma; K Sudo; M Muroi; T Kanamaru; H Okazaki
Journal:  J Antibiot (Tokyo)       Date:  1991-06       Impact factor: 2.649

2.  SQ 30,957, a new antibiotic produced by Penicillium funiculosum. Taxonomy, fermentation, isolation, structure determination, synthesis and antibacterial activity.

Authors:  P D Singh; J H Johnson; C A Aklonis; J O'Sullivan
Journal:  J Antibiot (Tokyo)       Date:  1986-08       Impact factor: 2.649

3.  Antiinflammatory activity of the new mould metabolite 11-desacetoxy-wortmannin and of some of its derivatives.

Authors:  D Wiesinger; H U Gubler; W Haefliger; D Hauser
Journal:  Experientia       Date:  1974-02-15

4.  Funiculosin, a new antibiotic. I. Isolation, biological and chemical properties (studies on antiviral and antitumor antibiotics. 8).

Authors:  K Ando; S Suzuki; T Saeki; G Tamura; K Arima
Journal:  J Antibiot (Tokyo)       Date:  1969-05       Impact factor: 2.649

5.  Free fatty acids identified as antitryptic factor in soybeans fermented by Rhizopus oligosporus.

Authors:  H L Wang; E W Swain; L L Wallen; C W Hesseltine
Journal:  J Nutr       Date:  1975-10       Impact factor: 4.798

Review 6.  Chemopreventive agents: protease inhibitors.

Authors:  A R Kennedy
Journal:  Pharmacol Ther       Date:  1998-06       Impact factor: 12.310

7.  Increased activity and stability of poly(ethylene glycol)-modified trypsin.

Authors:  H F Gaertner; A J Puigserver
Journal:  Enzyme Microb Technol       Date:  1992-02       Impact factor: 3.493

Review 8.  Prevention of carcinogenesis by protease inhibitors.

Authors:  A R Kennedy
Journal:  Cancer Res       Date:  1994-04-01       Impact factor: 12.701

9.  Production of (-)-mitorubrinic acid byPenicillium vermiculatum.

Authors:  B Proksa; M Sturdíková; S C Mojumdar; J Fuska
Journal:  Folia Microbiol (Praha)       Date:  1997-04       Impact factor: 2.629
  9 in total
  2 in total

1.  Microbial production of glyceric acid, an organic acid that can be mass produced from glycerol.

Authors:  Hiroshi Habe; Yuko Shimada; Toshiharu Yakushi; Hiromi Hattori; Yoshitaka Ano; Tokuma Fukuoka; Dai Kitamoto; Masayuki Itagaki; Kunihiro Watanabe; Hiroshi Yanagishita; Kazunobu Matsushita; Keiji Sakaki
Journal:  Appl Environ Microbiol       Date:  2009-10-16       Impact factor: 4.792

2.  Directed evolution of alditol oxidase for the production of optically pure D-glycerate from glycerol in the engineered Escherichia coli.

Authors:  Chao Zhang; Qian Chen; Feiyu Fan; Jinlei Tang; Tao Zhan; Honglei Wang; Xueli Zhang
Journal:  J Ind Microbiol Biotechnol       Date:  2021-08-24       Impact factor: 4.258
  2 in total

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