Literature DB >> 11500477

Characterization of the secreted MPT53 antigen of Mycobacterium tuberculosis.

S Johnson1, P Brusasca, K Lyashchenko, J S Spencer, H G Wiker, P Bifani, E Shashkina, B Kreiswirth, M Harboe, N Schluger, M Gomez, M L Gennaro.   

Abstract

MPT53 is a secreted protein of Mycobacterium tuberculosis. Southern transfer and hybridization showed mpt53 to be conserved in the M. tuberculosis complex and to have homology with DNA from Mycobacterium avium and other nontuberculous mycobacteria. However, anti-MPT53 polyclonal antibodies detected no antigen in the culture filtrates of M. avium and other nontuberculous mycobacteria. MPT53 of M. tuberculosis induced strong, tuberculosis-specific antibody responses in guinea pigs but induced no delayed-type hypersensitivity. Involvement in immune responses during human tuberculosis was very modest.

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Year:  2001        PMID： 11500477      PMCID： PMC98717          DOI： 10.1128/IAI.69.9.5936-5939.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

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