| Literature DB >> 11499629 |
A B Van Kuilenburg1, A E Stroomer, G J Peters, A H Van Gennip.
Abstract
F-beta-Alanine and beta-alanine were detected in plasma and urine samples with fluorescence detection of orthophthaldialdehyde derivatives of F-beta-alanine and beta-alanine after separation with dual-column reversed-phase HPLC. The detection limits of F-beta-alanine and beta-alanine in the HPLC system were approximately 0.3 and 0.7 pmol, respectively. The procedure proved to be very reproducible with intra-assay RSDs and inter-assay RSDs being less than 8%. The usefulness of the method was demonstrated by the analysis of the F-beta-alanine and beta-alanine concentrations in plasma and urine samples from tumor patients treated with S-1 (Tegafur, 5-chloro-2,4-dihydroxypyridine and potassium oxonate in a molar ratio of 1:0.4:1).Entities:
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Year: 2001 PMID： 11499629 DOI： 10.1016/s0378-4347(01)00203-1
Source DB: PubMed Journal: J Chromatogr B Biomed Sci Appl ISSN： 1387-2273