Literature DB >> 11498546

Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus.

M D Litt1, M Simpson, M Gaszner, C D Allis, G Felsenfeld.   

Abstract

Methylation of histones at specific residues plays an important role in transcriptional regulation. Chromatin immunoprecipitation of dimethylated lysine 9 on histone H3 across 53 kilobases of the chicken beta-globin locus during erythropoiesis shows an almost complete anticorrelation between regions of elevated lysine 9 methylation and acetylation. Lysine 9 is methylated most over constitutive condensed chromatin and developmentally inactive globin genes. In contrast, lysine 4 methylation of histone H3 correlates with H3 acetylation. These results lead us to propose a mechanism by which the insulator in the beta-globin locus can protect the globin genes from being silenced by adjacent condensed chromatin.

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Year:  2001        PMID： 11498546     DOI： 10.1126/science.1064413

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  206 in total

1.  SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.

Authors:  David C Schultz; Kasirajan Ayyanathan; Dmitri Negorev; Gerd G Maul; Frank J Rauscher
Journal:  Genes Dev       Date:  2002-04-15       Impact factor: 11.361

2.  Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.

Authors:  Kenichi Nishioka; Sergei Chuikov; Kavitha Sarma; Hediye Erdjument-Bromage; C David Allis; Paul Tempst; Danny Reinberg
Journal:  Genes Dev       Date:  2002-02-15       Impact factor: 11.361

3.  Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities.

Authors:  Félix Recillas-Targa; Michael J Pikaart; Bonnie Burgess-Beusse; Adam C Bell; Michael D Litt; Adam G West; Miklos Gaszner; Gary Felsenfeld
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-14       Impact factor: 11.205

4.  Protein:protein interactions and the pairing of boundary elements in vivo.

Authors:  Jason Blanton; Miklos Gaszner; Paul Schedl
Journal:  Genes Dev       Date:  2003-03-01       Impact factor: 11.361

5.  Balance between acetylation and methylation of histone H3 lysine 9 on the E2F-responsive dihydrofolate reductase promoter.

Authors:  Estelle Nicolas; Christine Roumillac; Didier Trouche
Journal:  Mol Cell Biol       Date:  2003-03       Impact factor: 4.272

6.  Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes.

Authors:  Cécile Fournier; Yuji Goto; Esteban Ballestar; Katia Delaval; Ann M Hever; Manel Esteller; Robert Feil
Journal:  EMBO J       Date:  2002-12-02       Impact factor: 11.598

7.  Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase.

Authors:  Xing Zhang; Hisashi Tamaru; Seema I Khan; John R Horton; Lisa J Keefe; Eric U Selker; Xiaodong Cheng
Journal:  Cell       Date:  2002-10-04       Impact factor: 41.582

Review 8.  Locus control regions.

Authors:  Qiliang Li; Kenneth R Peterson; Xiangdong Fang; George Stamatoyannopoulos
Journal:  Blood       Date:  2002-11-01       Impact factor: 22.113

9.  Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation.

Authors:  Evgenya Y Popova; Sharon Wald Krauss; Sarah A Short; Gloria Lee; Jonathan Villalobos; Joan Etzell; Mark J Koury; Paul A Ney; Joel Anne Chasis; Sergei A Grigoryev
Journal:  Chromosome Res       Date:  2009-01-27       Impact factor: 5.239

10.  Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome.

Authors:  Bradford Coffee; Fuping Zhang; Stephanie Ceman; Stephen T Warren; Daniel Reines
Journal:  Am J Hum Genet       Date:  2002-09-13       Impact factor: 11.025
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