Literature DB >> 11487275

CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation.

C Jones1, A V Nonni, L Fulford, S Merrett, R Chaggar, V Eusebi, S R Lakhani.   

Abstract

2-18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade III invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient. Copyright 2001 Cancer Research Campaign.

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Year:  2001        PMID： 11487275      PMCID： PMC2364069          DOI： 10.1054/bjoc.2001.1869

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  32 in total

1.  Genetic alterations in primary breast cancers and their metastases: direct comparison using modified comparative genomic hybridization.

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Journal:  Genes Chromosomes Cancer       Date:  1997-08       Impact factor: 5.006

2.  Malignant myoepithelioma of the breast metastasizing to the jaw.

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Review 3.  Carcinomas of the breast showing myoepithelial cell differentiation. A review of the literature.

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Journal:  Virchows Arch       Date:  1998-04       Impact factor: 4.064

4.  Molecular portraits of human breast tumours.

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Journal:  Nature       Date:  2000-08-17       Impact factor: 49.962

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6.  Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer.

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7.  Malignant myoepithelioma (myoepithelial carcinoma) of the breast: a detailed cytokeratin study.

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Journal:  J Clin Pathol       Date:  1995-02       Impact factor: 3.411

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Review 9.  Adenomyoepithelioma of the breast. A case report.

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10.  Immunohistochemical determination of oestrogen receptor: comparison of different methods of assessment of staining and correlation with clinical outcome of breast cancer patients.

Authors:  D M Barnes; W H Harris; P Smith; R R Millis; R D Rubens
Journal:  Br J Cancer       Date:  1996-11       Impact factor: 7.640
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  37 in total

1.  Collagen gel contraction serves to rapidly distinguish epithelial- and mesenchymal-derived cells irrespective of alpha-smooth muscle actin expression.

Authors:  Helga Lind Nielsen; Thorarinn Gudjonsson; René Villadsen; Lone Rønnov-Jessen; Ole William Petersen
Journal:  In Vitro Cell Dev Biol Anim       Date:  2003 Jul-Aug       Impact factor: 2.416

Review 2.  Molecular therapy of breast cancer: progress and future directions.

Authors:  Sheng-Xiang Lin; Jiong Chen; Mausumi Mazumdar; Donald Poirier; Cheng Wang; Arezki Azzi; Ming Zhou
Journal:  Nat Rev Endocrinol       Date:  2010-07-20       Impact factor: 43.330

3.  [The significance of "normal tissue" in the development of breast cancer: new concepts of early carcinogenesis].

Authors:  H Bürger; C Kersting; D Hungermann; T Decker; W Böcker
Journal:  Pathologe       Date:  2006-09       Impact factor: 1.011

Review 4.  Myoepithelial cells: pathology, cell separation and markers of myoepithelial differentiation.

Authors:  Catherine Clarke; Jennifer Sandle; Sunil R Lakhani
Journal:  J Mammary Gland Biol Neoplasia       Date:  2005-07       Impact factor: 2.673

5.  Eccrine ductal and acrosyringeal differentiation of the breast epithelium--a lesion associated with some metaplastic breast carcinomas.

Authors:  Tibor Tot
Journal:  Virchows Arch       Date:  2006-10-03       Impact factor: 4.064

6.  Basaloid carcinoma of the pancreas.

Authors:  Gianluca Marucci; Christine M Betts; Luciano Liguori; Vincenzo Eusebi
Journal:  Virchows Arch       Date:  2005-02-22       Impact factor: 4.064

Review 7.  Salivary gland-like tumours of the breast: surgical and molecular pathology.

Authors:  M Pia-Foschini; J S Reis-Filho; V Eusebi; S R Lakhani
Journal:  J Clin Pathol       Date:  2003-07       Impact factor: 3.411

Review 8.  Demystifying basal-like breast carcinomas.

Authors:  L Da Silva; C Clarke; S R Lakhani
Journal:  J Clin Pathol       Date:  2007-05-11       Impact factor: 3.411

9.  Chromogenic in situ hybridization for alpha6beta4 integrin in breast cancer: correlation with protein expression.

Authors:  Leslie K Diaz; Xiao Zhou; Kristin Welch; Aysegul Sahin; Michael Z Gilcrease
Journal:  J Mol Diagn       Date:  2004-02       Impact factor: 5.568

10.  The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.

Authors:  E Y Tan; M Yan; L Campo; C Han; E Takano; H Turley; I Candiloro; F Pezzella; K C Gatter; E K A Millar; S A O'Toole; C M McNeil; P Crea; D Segara; R L Sutherland; A L Harris; S B Fox
Journal:  Br J Cancer       Date:  2009-01-27       Impact factor: 7.640
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