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Literature DB >> 11486023

Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway.

T Naiki¹, T Kondo, D Nakada, K Matsumoto, K Sugimoto.

Abstract

RAD24 has been identified as a gene essential for the DNA damage checkpoint in budding yeast. Rad24 is structurally related to subunits of the replication factor C (RFC) complex, and forms an RFC-related complex with Rfc2, Rfc3, Rfc4, and Rfc5. The rad24Delta mutation enhances the defect of rfc5-1 in the DNA replication block checkpoint, implicating RAD24 in this checkpoint. CHL12 (also called CTF18) encodes a protein that is structurally related to the Rad24 and RFC proteins. We show here that although neither chl12Delta nor rad24Delta single mutants are defective, chl12Delta rad24Delta double mutants become defective in the replication block checkpoint. We also show that Chl12 interacts physically with Rfc2, Rfc3, Rfc4, and Rfc5 and forms an RFC-related complex which is distinct from the RFC and RAD24 complexes. Our results suggest that Chl12 forms a novel RFC-related complex and functions redundantly with Rad24 in the DNA replication block checkpoint.

Entities: Gene Species

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Year: 2001 PMID： 11486023 PMCID： PMC87303 DOI： 10.1128/MCB.21.17.5838-5845.2001

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

33 in total

1. A novel Rad24 checkpoint protein complex closely related to replication factor C.

Authors: C M Green; H Erdjument-Bromage; P Tempst; N F Lowndes
Journal: Curr Biol Date: 2000-01-13 Impact factor: 10.834

Review 2. The DNA damage response: putting checkpoints in perspective.

Authors: B B Zhou; S J Elledge
Journal: Nature Date: 2000-11-23 Impact factor: 49.962

3. Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes.

Authors: C Venclovas; M P Thelen
Journal: Nucleic Acids Res Date: 2000-07-01 Impact factor: 16.971

4. A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins.

Authors: M P Thelen; C Venclovas; K Fidelis
Journal: Cell Date: 1999-03-19 Impact factor: 41.582

5. Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae.

Authors: T Wakayama; T Kondo; S Ando; K Matsumoto; K Sugimoto
Journal: Mol Cell Biol Date: 2001-02 Impact factor: 4.272

6. The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci.

Authors: C Frei; S M Gasser
Journal: Genes Dev Date: 2000-01-01 Impact factor: 11.361

7. The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast.

Authors: V Paciotti; M Clerici; G Lucchini; M P Longhese
Journal: Genes Dev Date: 2000-08-15 Impact factor: 11.361

8. Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae.

Authors: T Naiki; T Shimomura; T Kondo; K Matsumoto; K Sugimoto
Journal: Mol Cell Biol Date: 2000-08 Impact factor: 4.272

9. G2/M checkpoint genes of Saccharomyces cerevisiae: further evidence for roles in DNA replication and/or repair.

Authors: D Lydall; T Weinert
Journal: Mol Gen Genet Date: 1997-11

10. LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae.

Authors: J Rouse; S P Jackson
Journal: EMBO J Date: 2000-11-01 Impact factor: 11.598

59 in total

1. S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion.

Authors: Cheryl D Warren; D Mark Eckley; Marina S Lee; Joseph S Hanna; Adam Hughes; Brian Peyser; Chunfa Jie; Rafael Irizarry; Forrest A Spencer
Journal: Mol Biol Cell Date: 2004-01-23 Impact factor: 4.138

2. Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.

Authors: Alexander J Osborn; Stephen J Elledge
Journal: Genes Dev Date: 2003-07-15 Impact factor: 11.361

3. Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process.

Authors: Ceslovas Venclovas; Michael E Colvin; Michael P Thelen
Journal: Protein Sci Date: 2002-10 Impact factor: 6.725

4. The origin recognition complex links replication, sister chromatid cohesion and transcriptional silencing in Saccharomyces cerevisiae.

Authors: Bernhard Suter; Amy Tong; Michael Chang; Lisa Yu; Grant W Brown; Charles Boone; Jasper Rine
Journal: Genetics Date: 2004-06 Impact factor: 4.562

5. Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance.

Authors: Lyne Khair; Ya-Ting Chang; Lakxmi Subramanian; Paul Russell; Toru M Nakamura
Journal: Cell Cycle Date: 2010-06-01 Impact factor: 4.534

10. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.

Authors: Vladimir P Bermudez; Yoshimasa Maniwa; Inger Tappin; Keiko Ozato; Kyoko Yokomori; Jerard Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 2003-08-20 Impact factor: 11.205