Literature DB >> 11485332

Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase.

C L Soong1, J Ogawa, S Shimizu.   

Abstract

Amidohydrolytic reactions in oxidative pyrimidine metabolism were investigated in detail. Barbiturase has been reported to catalyze the amidohydrolysis of barbituric acid to urea and malonic acid. However, purification of the enzyme revealed that it catalyzes the ring-opening of barbituric acid to ureidomalonic acid. The existence of a consecutive enzyme named ureidomalonase, which hydrolyzes ureidomalonic acid to urea and malonic acid, was also discovered during the purification of barbiturase. Copyright 2001 Academic Press.

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Year:  2001        PMID： 11485332     DOI： 10.1006/bbrc.2001.5356

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  14 in total

1.  Allophanate hydrolase, not urease, functions in bacterial cyanuric acid metabolism.

Authors:  Gang Cheng; Nir Shapir; Michael J Sadowsky; Lawrence P Wackett
Journal:  Appl Environ Microbiol       Date:  2005-08       Impact factor: 4.792

2.  Crystallization and preliminary X-ray diffraction analysis of cyclic imide hydrolase (CIH) from Pseudomonas putida YZ-26.

Authors:  Zheng Fan; Jianxun Qi; Yawei Shi; Yiwei Liu
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-03-30

3.  Defining sequence space and reaction products within the cyanuric acid hydrolase (AtzD)/barbiturase protein family.

Authors:  Jennifer L Seffernick; Jasmine S Erickson; Stephan M Cameron; Seunghee Cho; Anthony G Dodge; Jack E Richman; Michael J Sadowsky; Lawrence P Wackett
Journal:  J Bacteriol       Date:  2012-06-22       Impact factor: 3.490

Review 4.  Ancient Evolution and Recent Evolution Converge for the Biodegradation of Cyanuric Acid and Related Triazines.

Authors:  Jennifer L Seffernick; Lawrence P Wackett
Journal:  Appl Environ Microbiol       Date:  2016-01-04       Impact factor: 4.792

5.  Crystallization and preliminary X-ray diffraction studies of cyanuric acid hydrolase from Azorhizobium caulinodans.

Authors:  Seunghee Cho; Ke Shi; Lawrence P Wackett; Hideki Aihara
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2013-07-27

6.  High-Resolution X-Ray Structures of Two Functionally Distinct Members of the Cyclic Amide Hydrolase Family of Toblerone Fold Enzymes.

Authors:  Thomas S Peat; Sahil Balotra; Matthew Wilding; Carol J Hartley; Janet Newman; Colin Scott
Journal:  Appl Environ Microbiol       Date:  2017-04-17       Impact factor: 4.792

7.  On the origins of cyanuric acid hydrolase: purification, substrates, and prevalence of AtzD from Pseudomonas sp. strain ADP.

Authors:  Isaac Fruchey; Nir Shapir; Michael J Sadowsky; Lawrence P Wackett
Journal:  Appl Environ Microbiol       Date:  2003-06       Impact factor: 4.792

8.  A previously undescribed pathway for pyrimidine catabolism.

Authors:  Kevin D Loh; Prasad Gyaneshwar; Eirene Markenscoff Papadimitriou; Rebecca Fong; Kwang-Seo Kim; Rebecca Parales; Zhongrui Zhou; William Inwood; Sydney Kustu
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-15       Impact factor: 11.205

9.  Cyanuric Acid Biodegradation via Biuret: Physiology, Taxonomy, and Geospatial Distribution.

Authors:  Kelly G Aukema; Lambros J Tassoulas; Serina L Robinson; Jessica F Konopatski; Madison D Bygd; Lawrence P Wackett
Journal:  Appl Environ Microbiol       Date:  2020-01-07       Impact factor: 4.792

10.  Global expression analysis of the yeast Lachancea (Saccharomyces) kluyveri reveals new URC genes involved in pyrimidine catabolism.

Authors:  Anna Andersson Rasmussen; Dineshkumar Kandasamy; Halfdan Beck; Seth D Crosby; Olof Björnberg; Klaus D Schnackerz; Jure Piškur
Journal:  Eukaryot Cell       Date:  2013-11-01
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