Literature DB >> 11484798

High frequency of the HIV-1 protective CCR5 delta32 deletion in native Estonians.

I Kalev1, A V Mikelsaar, L Beckman, G Tasa, P Pärlist.   

Abstract

In previous studies, the highest frequencies (16%) of the CCR5 delta32 deletion have been found in populations of Finno-Ugric origin. We here report a high CCR5 delta32 frequency (15%) in another Finno-Ugric populations, the Estonians. The highest frequency (18%) was found on the geographically isolated Estonian island of Dagö. We examined 504 healthy unrelated individuals of Estonian nationality, whose grandparents were born in Estonia. The polymerase chain reaction assay was performed and the amplified products were digested with EcoRI.

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Year:  2000        PMID： 11484798     DOI： 10.1023/a:1010829816334

Source DB:  PubMed          Journal:  Eur J Epidemiol        ISSN： 0393-2990            Impact factor:   8.082


  18 in total

1.  Absence of the deltaccr5 mutation in indigenous populations of the Brazilian Amazon.

Authors:  A P Leboute; M W de Carvalho; A L Simões
Journal:  Hum Genet       Date:  1999-11       Impact factor: 4.132

2.  Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.

Authors:  A Maho; A Bensimon; G Vassart; M Parmentier
Journal:  Cytogenet Cell Genet       Date:  1999

3.  Reduced HIV-1 infectability of CD4+ lymphocytes from exposed-uninfected individuals: association with low expression of CCR5 and high production of beta-chemokines.

Authors:  W A Paxton; R Liu; S Kang; L Wu; T R Gingeras; N R Landau; C R Mackay; R A Koup
Journal:  Virology       Date:  1998-04-25       Impact factor: 3.616

4.  Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes.

Authors:  J C Stephens; D E Reich; D B Goldstein; H D Shin; M W Smith; M Carrington; C Winkler; G A Huttley; R Allikmets; L Schriml; B Gerrard; M Malasky; M D Ramos; S Morlot; M Tzetis; C Oddoux; F S di Giovine; G Nasioulas; D Chandler; M Aseev; M Hanson; L Kalaydjieva; D Glavac; P Gasparini; E Kanavakis; M Claustres; M Kambouris; H Ostrer; G Duff; V Baranov; H Sibul; A Metspalu; D Goldman; N Martin; D Duffy; J Schmidtke; X Estivill; S J O'Brien; M Dean
Journal:  Am J Hum Genet       Date:  1998-06       Impact factor: 11.025

5.  The extent of genetic variation in the CCR5 gene.

Authors:  M A Ansari-Lari; X M Liu; M L Metzker; A R Rut; R A Gibbs
Journal:  Nat Genet       Date:  1997-07       Impact factor: 38.330

6.  The deltaccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe.

Authors:  F Libert; P Cochaux; G Beckman; M Samson; M Aksenova; A Cao; A Czeizel; M Claustres; C de la Rúa; M Ferrari; C Ferrec; G Glover; B Grinde; S Güran; V Kucinskas; J Lavinha; B Mercier; G Ogur; L Peltonen; C Rosatelli; M Schwartz; V Spitsyn; L Timar; L Beckman; M Parmentier; G Vassart
Journal:  Hum Mol Genet       Date:  1998-03       Impact factor: 6.150

7.  Global distribution of the CCR5 gene 32-basepair deletion.

Authors:  J J Martinson; N H Chapman; D C Rees; Y T Liu; J B Clegg
Journal:  Nat Genet       Date:  1997-05       Impact factor: 38.330

8.  The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.

Authors:  Y Huang; W A Paxton; S M Wolinsky; A U Neumann; L Zhang; T He; S Kang; D Ceradini; Z Jin; K Yazdanbakhsh; K Kunstman; D Erickson; E Dragon; N R Landau; J Phair; D D Ho; R A Koup
Journal:  Nat Med       Date:  1996-11       Impact factor: 53.440

9.  CC chemokine receptor 5-mediated signaling and HIV-1 Co-receptor activity share common structural determinants. Critical residues in the third extracellular loop support HIV-1 fusion.

Authors:  G Alkhatib; S S Ahuja; D Light; S Mummidi; E A Berger; S K Ahuja
Journal:  J Biol Chem       Date:  1997-08-08       Impact factor: 5.157

10.  Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.

Authors:  M Samson; F Libert; B J Doranz; J Rucker; C Liesnard; C M Farber; S Saragosti; C Lapoumeroulie; J Cognaux; C Forceille; G Muyldermans; C Verhofstede; G Burtonboy; M Georges; T Imai; S Rana; Y Yi; R J Smyth; R G Collman; R W Doms; G Vassart; M Parmentier
Journal:  Nature       Date:  1996-08-22       Impact factor: 49.962
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  4 in total

1.  Evaluating plague and smallpox as historical selective pressures for the CCR5-Delta 32 HIV-resistance allele.

Authors:  Alison P Galvani; Montgomery Slatkin
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-25       Impact factor: 11.205

2.  Mutation in AIDS restriction gene affecting HIV infection and disease progression in a high risk group from Northeastern India.

Authors:  Partha Roy; Sekhar Chakrabarti
Journal:  Med J Armed Forces India       Date:  2016-02-06

3.  The geographic spread of the CCR5 Delta32 HIV-resistance allele.

Authors:  John Novembre; Alison P Galvani; Montgomery Slatkin
Journal:  PLoS Biol       Date:  2005-10-18       Impact factor: 8.029

4.  Polymorphisms in CCR5Δ32 and Risk of HIV-1 Infection in the Southeast of Caspian Sea, Iran.

Authors:  Zahra Heydarifard; Alijan Tabarraei; Abdolvahab Moradi
Journal:  Dis Markers       Date:  2017-10-25       Impact factor: 3.434
  4 in total

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