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Literature DB >> 1148097

Pharmacology of local anaesthetic agents. Pharmacokinetics of local anaesthetic agents.

Abstract

Information derived from measurements of blood concentrations of local anaesthetics can be extended by the application of pharmacokinetic anaylsis. A better understanding of quantitative aspects of the disposition and absorption of these drugs should assist the anaesthetist in deciding the optimal agent and dosage for regional block techniques.

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Year: 1975 PMID： 1148097

Source DB: PubMed Journal: Br J Anaesth ISSN： 0007-0912 Impact factor: 9.166

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Cited

33 in total

Review 1. Anatomical-physiological approaches in pharmacokinetics and pharmacodynamics.

Authors: L E Mather
Journal: Clin Pharmacokinet Date: 2001 Impact factor: 6.447

2. The effect of age on the systemic absorption, disposition and pharmacodynamics of bupivacaine after epidural administration.

Authors: B T Veering; A G Burm; A A Vletter; R P van den Heuvel; W Onkenhout; J Spierdijk
Journal: Clin Pharmacokinet Date: 1992-01 Impact factor: 6.447

3. General theory for rapidly establishing steady state drug concentrations using two consecutive constant rate intravenous infusions.

Authors: D P Vaughan; G T Tucker
Journal: Eur J Clin Pharmacol Date: 1975-12-19 Impact factor: 2.953

Review 4. Local anesthetics.

Authors: J A Yagiela
Journal: Anesth Prog Date: 1991 Jul-Oct

Pharmacology of local anaesthetic agents. Pharmacokinetics of local anaesthetic agents.

Review 1. Anatomical-physiological approaches in pharmacokinetics and pharmacodynamics.

2. The effect of age on the systemic absorption, disposition and pharmacodynamics of bupivacaine after epidural administration.

3. General theory for rapidly establishing steady state drug concentrations using two consecutive constant rate intravenous infusions.

Review 4. Local anesthetics.

5. Pharmacokinetics of bupivacaine enantiomers in sheep: influence of dosage regimen and study design.

Review 6. Clinical pharmacokinetics of epidural and spinal anaesthesia.

7. Rational use of local anaesthetics.

8. Patient-controlled analgesic therapy. Part I: Pharmacokinetics of pethidine in the per- and postoperative periods.

9. Plasma protein binding of etidocaine during pregnancy and labour.

10. Patient-controlled analgesic therapy, Part IV: pharmacokinetics and analgesic plasma concentrations of morphine.