Literature DB >> 11479367

Molecular recognition by induced fit: how fit is the concept?

H R Bosshard1.   

Abstract

Induced fit explains why biomolecules can bind together even if they are not optimized for binding. However, induced fit can lead to a kinetic bottleneck and does not describe every interaction in the absence of prior complementarity. Preselection of a fitting conformer is an alternative to induced fit.

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Year:  2001        PMID： 11479367     DOI： 10.1152/physiologyonline.2001.16.4.171

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  76 in total

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5.  On the roles of substrate binding and hinge unfolding in conformational changes of adenylate kinase.

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Journal:  Biophys J       Date:  2010-11-17       Impact factor: 4.033

6.  Computational docking simulations of a DNA-aptamer for argininamide and related ligands.

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7.  Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism.

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Journal:  EMBO Rep       Date:  2004-11       Impact factor: 8.807

8.  Characterization of the solution structure of the M intermediate of photoactive yellow protein using high-angle solution x-ray scattering.

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9.  Dynamic energy landscape view of coupled binding and protein conformational change: induced-fit versus population-shift mechanisms.

Authors:  Kei-Ichi Okazaki; Shoji Takada
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-04       Impact factor: 11.205

10.  Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands.

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Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-08       Impact factor: 11.205
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