Literature DB >> 11479119

Lead compounds discovered from libraries.

A Golebiowski1, S R Klopfenstein, D E Portlock.   

Abstract

Lead compounds with the potential to progress to viable drug candidates have been identified from libraries using several strategies. These include rapid screening of large diverse collections, thematic libraries, project-directed libraries, and three-dimensional molecular models of corporate databases. There have been numerous success stories, including the identification of several clinical candidates.

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Year:  2001        PMID： 11479119     DOI： 10.1016/s1367-5931(00)00203-9

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  9 in total

1.  Compound library development guided by protein structure similarity clustering and natural product structure.

Authors:  Marcus A Koch; Lars-Oliver Wittenberg; Sudipta Basu; Duraiswamy A Jeyaraj; Eleni Gourzoulidou; Kerstin Reinecke; Alex Odermatt; Herbert Waldmann
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-17       Impact factor: 11.205

Review 2.  Structure-based discovery of antibacterial drugs.

Authors:  Katie J Simmons; Ian Chopra; Colin W G Fishwick
Journal:  Nat Rev Microbiol       Date:  2010-07       Impact factor: 60.633

Review 3.  Solid-supported reagents and catalysts for the preparation of large ring compounds.

Authors:  Elisabeth Gonthier; Rolf Breinbauer
Journal:  Mol Divers       Date:  2005       Impact factor: 2.943

4.  VolSurf analysis of pharmacokinetic properties for several antifungal sesquiterpene lactones isolated from Greek Centaurea sp.

Authors:  Catherine Koukoulitsa; George D Geromichalos; Helen Skaltsa
Journal:  J Comput Aided Mol Des       Date:  2005-10-28       Impact factor: 3.686

5.  A Multimodal Data Analysis Approach for Targeted Drug Discovery Involving Topological Data Analysis (TDA).

Authors:  Muthuraman Alagappan; Dadi Jiang; Nicholas Denko; Albert C Koong
Journal:  Adv Exp Med Biol       Date:  2016       Impact factor: 2.622

6.  A new strategy for solid phase synthesis of a secondary amide library using sulfonamide linker via radical traceless cleavage.

Authors:  Juntao Luo; Wenqiang Huang
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

7.  Decoration of dihydropyrimidine and dihydropyridine scaffolds with sugars via Biginelli and Hantzsch multicomponent reactions: an efficient entry to a collection of artificial nucleosides.

Authors:  Alessandro Dondoni; Alessandro Massi
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

Review 8.  Insight into the Development of PET Radiopharmaceuticals for Oncology.

Authors:  Joseph Lau; Etienne Rousseau; Daniel Kwon; Kuo-Shyan Lin; François Bénard; Xiaoyuan Chen
Journal:  Cancers (Basel)       Date:  2020-05-21       Impact factor: 6.639

9.  CuI nanoparticle-catalyzed synthesis of tetracyclic benzo[e]benzo[4,5]imidazo[1,2-c][1,3]thiazin-6-imine heterocycles by SNAr-type C-S, C-N bond formation from isothiocyanatobenzenes and benzimidazoles.

Authors:  Xiaolong Guo; Luyao Wang; Jing Hu; Mengmeng Zhang
Journal:  RSC Adv       Date:  2018-06-19       Impact factor: 4.036
  9 in total

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