Literature DB >> 11478951

Cone venom--from accidental stings to deliberate injection.

J M McIntosh1, R M Jones.   

Abstract

Cone snails have long been of note due to their colorful shells and deadly venom. Over the years, a number of people who have encountered these molluscs have been injured or killed by their sting. Biochemical analysis of the venom components has revealed a plethora of peptides and proteins that target a variety of receptors and ion channels. Pharmaceutical companies are now utilizing the selectivity and potency of Conus-derived peptides to develop novel medications for pain, epilepsy and other disorders.

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Year:  2001        PMID： 11478951     DOI： 10.1016/s0041-0101(01)00145-3

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  21 in total

1.  Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history.

Authors:  C A Elliger; T A Richmond; Z N Lebaric; N T Pierce; J V Sweedler; W F Gilly
Journal:  Toxicon       Date:  2010-12-21       Impact factor: 3.033

2.  Glycine-rich conotoxins from the Virgiconus clade.

Authors:  Samuel S Espino; Taleen Dilanyan; Julita S Imperial; Manuel B Aguilar; Russell W Teichert; Pradip Bandyopadhyay; Baldomero M Olivera
Journal:  Toxicon       Date:  2016-02-04       Impact factor: 3.033

3.  A diverse family of novel peptide toxins from an unusual cone snail, Conus californicus.

Authors:  W F Gilly; T A Richmond; T F Duda; C Elliger; Z Lebaric; J Schulz; J P Bingham; J V Sweedler
Journal:  J Exp Biol       Date:  2011-01-01       Impact factor: 3.312

4.  Synthesis of fluorescent analogs of alpha-conotoxin MII.

Authors:  Vijay A Vishwanath; J Michael McIntosh
Journal:  Bioconjug Chem       Date:  2006 Nov-Dec       Impact factor: 4.774

Review 5.  Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.

Authors:  Layla Azam; J Michael McIntosh
Journal:  Acta Pharmacol Sin       Date:  2009-05-18       Impact factor: 6.150

6.  Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom.

Authors:  Sébastien Dutertre; Ai-hua Jin; Quentin Kaas; Alun Jones; Paul F Alewood; Richard J Lewis
Journal:  Mol Cell Proteomics       Date:  2012-11-14       Impact factor: 5.911

7.  Custom distinctions in the interaction of G-protein beta subunits with N-type (CaV2.2) versus P/Q-type (CaV2.1) calcium channels.

Authors:  Heather L Agler; Jenafer Evans; Henry M Colecraft; David T Yue
Journal:  J Gen Physiol       Date:  2003-06       Impact factor: 4.086

Review 8.  Combinatorial biosynthesis of RiPPs: docking with marine life.

Authors:  Debosmita Sardar; Eric W Schmidt
Journal:  Curr Opin Chem Biol       Date:  2015-12-19       Impact factor: 8.822

Review 9.  Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads.

Authors:  Christopher J Armishaw
Journal:  Toxins (Basel)       Date:  2010-06-14       Impact factor: 4.546

10.  Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct.

Authors:  Hao Hu; Pradip K Bandyopadhyay; Baldomero M Olivera; Mark Yandell
Journal:  BMC Genomics       Date:  2012-06-28       Impact factor: 3.969
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