| Literature DB >> 11473418 |
K Iwasa1, M Moriyasu, T Yamori, T Turuo, D U Lee, W Wiegrebe.
Abstract
In vitro cytotoxic activities of 24 quaternary protoberberine alkaloids related to berberine have been evaluated using a human cancer cell line panel coupled with a drug sensitivity database. Extending the alkyl chain at position 8 or 13 strongly influenced the cytotoxic activity, that is, relative lipophilicity as well as the size of the substituent affects cytotoxicity. The highest level of activity was observed in 8- or 13-hexyl-substituted derivatives of berberine. Structure-activity relationships are described.Entities:
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Year: 2001 PMID： 11473418 DOI： 10.1021/np000554f
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050