Literature DB >> 11472863

Abnormal neuronal network in anorexia nervosa studied with I-123-IMP SPECT.

A Takano1, T Shiga, N Kitagawa, T Koyama, C Katoh, E Tsukamoto, N Tamaki.   

Abstract

Single photon emission computed tomography was used to study 14 female patients with anorexia nervosa and 8 female normal comparison subjects. Automatic voxel-based analysis of the images was carried out using statistical parametric mapping (SPM) software. Statistics across the entire brain were displayed as Z scores (threshold: P<0.05). Compared with the normal comparison subjects, the anorectic patients were characterized by hypoperfusion in the medial prefrontal cortex and the anterior cingulate gyrus, and hyperperfusion in the thalamus and the amygdala-hippocampus complex. These results suggest that a dysfunction in neuronal circuitry may be related to anorexia nervosa.

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Year:  2001        PMID： 11472863     DOI： 10.1016/s0925-4927(01)00093-2

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


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