OBJECTIVE: Converging evidence suggests a role for the anterior cingulate cortex (ACC) in the pathophysiology of anorexia nervosa (AN). This study sought to determine whether ACC volume was affected by starvation in active AN and, if so, whether this had any clinical significance. METHOD: Eighteen patients with active AN and age- and gender-matched normal controls underwent magnetic resonance imaging (MRI). Sixteen patients (89%) with AN had intelligence quotients (IQ) testing at intake, 14 (78%) had repeat MRIs after weight normalization, and 10 (56%) had outcome data at 1-year posthospitalization. RESULTS: Right dorsal ACC volume was significantly reduced in active AN patients versus controls and was correlated with lower performance IQ. While ACC normalization occurred with weight restoration, smaller change in right dorsal ACC volume prospectively predicted relapse after treatment. CONCLUSION: Reduced right dorsal ACC volume during active AN relates to deficits in perceptual organization and conceptual reasoning. The degree of right dorsal ACC normalization during treatment is related to outcome.
OBJECTIVE: Converging evidence suggests a role for the anterior cingulate cortex (ACC) in the pathophysiology of anorexia nervosa (AN). This study sought to determine whether ACC volume was affected by starvation in active AN and, if so, whether this had any clinical significance. METHOD: Eighteen patients with active AN and age- and gender-matched normal controls underwent magnetic resonance imaging (MRI). Sixteen patients (89%) with AN had intelligence quotients (IQ) testing at intake, 14 (78%) had repeat MRIs after weight normalization, and 10 (56%) had outcome data at 1-year posthospitalization. RESULTS: Right dorsal ACC volume was significantly reduced in active AN patients versus controls and was correlated with lower performance IQ. While ACC normalization occurred with weight restoration, smaller change in right dorsal ACC volume prospectively predicted relapse after treatment. CONCLUSION: Reduced right dorsal ACC volume during active AN relates to deficits in perceptual organization and conceptual reasoning. The degree of right dorsal ACC normalization during treatment is related to outcome.
Authors: S M Rao; J A Bobholz; T A Hammeke; A C Rosen; S J Woodley; J M Cunningham; R W Cox; E A Stein; J R Binder Journal: Neuroreport Date: 1997-05-27 Impact factor: 1.837
Authors: H Boecker; A Dagher; A O Ceballos-Baumann; R E Passingham; M Samuel; K J Friston; J Poline; C Dettmers; B Conrad; D J Brooks Journal: J Neurophysiol Date: 1998-02 Impact factor: 2.714
Authors: Stella Blasel; Ulrich Pilatus; Joerg Magerkurth; Maya von Stauffenberg; Dmitri Vronski; Manuel Mueller; Lars Woeckel; Elke Hattingen Journal: Neuroradiology Date: 2012-01-03 Impact factor: 2.804
Authors: Christina A Roberto; Laurel E S Mayer; Adam M Brickman; Anna Barnes; Jordan Muraskin; Lok-Kin Yeung; Jason Steffener; Melissa Sy; Joy Hirsch; Yaakov Stern; B Timothy Walsh Journal: Int J Eat Disord Date: 2010-05-19 Impact factor: 4.861