| Literature DB >> 11472221 |
B B Lohray1, V B Lohray, A C Bajji, S Kalchar, R R Poondra, S Padakanti, R Chakrabarti, R K Vikramadithyan, P Misra, S Juluri, N V Mamidi, R Rajagopalan.
Abstract
(-)DRF 2725 (6) is a phenoxazine analogue of phenyl propanoic acid. Compound 6 showed interesting dual activation of PPAR alpha and PPAR gamma. In insulin resistant db/db mice, 6 showed better reduction of plasma glucose and triglyceride levels as compared to rosiglitazone. Compound 6 has also shown good oral bioavailability and impressive pharmacokinetic characteristics. Our study indicates that 6 has great potential as a drug for diabetes and dyslipidemia.Entities:
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Year: 2001 PMID： 11472221 DOI： 10.1021/jm010143b
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446