Literature DB >> 16905700

PPARgamma as a new therapeutic target in inflammatory bowel diseases.

L Dubuquoy1, C Rousseaux, X Thuru, L Peyrin-Biroulet, O Romano, P Chavatte, M Chamaillard, P Desreumaux.   

Abstract

The peroxisome proliferator activated receptor gamma(PPARgamma) is a nuclear receptor highly expressed in the colon and playing a key role in bacterial induced inflammation. Regulation of colon inflammation by this receptor has been well demonstrated in many experimental models of colitis but also in patients with ulcerative colitis, characterised by impaired expression of PPARgamma confined to their colon epithelial cells. Recent data showing that PPARgamma was the major functional receptor mediating the common aminosalicylate activities in inflammatory bowel diseases (IBD) have also reinforced the roles of this receptor in the control of intestinal inflammation. The aims of this review are to discuss the potential roles of PPARgamma in the physiopathology of IBD, as well as the emerging therapeutic strategies targeting this receptor.

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Year:  2006        PMID： 16905700      PMCID： PMC1860011          DOI： 10.1136/gut.2006.093484

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  80 in total

1.  The organization, promoter analysis, and expression of the human PPARgamma gene.

Authors:  L Fajas; D Auboeuf; E Raspé; K Schoonjans; A M Lefebvre; R Saladin; J Najib; M Laville; J C Fruchart; S Deeb; A Vidal-Puig; J Flier; M R Briggs; B Staels; H Vidal; J Auwerx
Journal:  J Biol Chem       Date:  1997-07-25       Impact factor: 5.157

Review 2.  PPARgamma in monocytes: less pain, any gain?

Authors:  B M Spiegelman
Journal:  Cell       Date:  1998-04-17       Impact factor: 41.582

3.  Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.

Authors:  J M Lehmann; J M Lenhard; B B Oliver; G M Ringold; S A Kliewer
Journal:  J Biol Chem       Date:  1997-02-07       Impact factor: 5.157

4.  Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.

Authors:  Pratik V Devasthale; Sean Chen; Yoon Jeon; Fucheng Qu; Chunning Shao; Wei Wang; Hao Zhang; Michael Cap; Dennis Farrelly; Rajasree Golla; Gary Grover; Thomas Harrity; Zhengping Ma; Lisa Moore; Jimmy Ren; Ramakrishna Seethala; Lin Cheng; Paul Sleph; Wei Sun; Aaron Tieman; John R Wetterau; Arthur Doweyko; Gamini Chandrasena; Shu Y Chang; W Griffith Humphreys; Vito G Sasseville; Scott A Biller; Denis E Ryono; Fred Selan; Narayanan Hariharan; Peter T W Cheng
Journal:  J Med Chem       Date:  2005-03-24       Impact factor: 7.446

Review 5.  Peroxisome proliferator-activated receptors, orphans with ligands and functions.

Authors:  K Schoonjans; G Martin; B Staels; J Auwerx
Journal:  Curr Opin Lipidol       Date:  1997-06       Impact factor: 4.776

6.  Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms.

Authors:  Katherine L Schaefer; Svetlana Denevich; Chen Ma; Shane R Cooley; Atsushi Nakajima; Koichiro Wada; Jennifer Schlezinger; David Sherr; Lawrence J Saubermann
Journal:  Inflamm Bowel Dis       Date:  2005-03       Impact factor: 5.325

7.  Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.

Authors:  A J Vidal-Puig; R V Considine; M Jimenez-Liñan; A Werman; W J Pories; J F Caro; J S Flier
Journal:  J Clin Invest       Date:  1997-05-15       Impact factor: 14.808

8.  Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.

Authors:  S A Kliewer; S S Sundseth; S A Jones; P J Brown; G B Wisely; C S Koble; P Devchand; W Wahli; T M Willson; J M Lenhard; J M Lehmann
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-29       Impact factor: 11.205

9.  Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

Authors:  A Vidal-Puig; M Jimenez-Liñan; B B Lowell; A Hamann; E Hu; B Spiegelman; J S Flier; D E Moller
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

10.  Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma.

Authors:  Christel Rousseaux; Bruno Lefebvre; Laurent Dubuquoy; Philippe Lefebvre; Olivier Romano; Johan Auwerx; Daniel Metzger; Walter Wahli; Béatrice Desvergne; Gian Carlo Naccari; Philippe Chavatte; Amaury Farce; Philippe Bulois; Antoine Cortot; Jean Frédéric Colombel; Pierre Desreumaux
Journal:  J Exp Med       Date:  2005-04-11       Impact factor: 14.307
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  121 in total

1.  PPAR signaling pathway and cancer-related proteins are involved in celiac disease-associated tissue damage.

Authors:  Maria Paola Simula; Renato Cannizzaro; Vincenzo Canzonieri; Alessandro Pavan; Stefania Maiero; Giuseppe Toffoli; Valli De Re
Journal:  Mol Med       Date:  2010-03-03       Impact factor: 6.354

Review 2.  15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?

Authors:  Sun Il Lee; Xiangsheng Zuo; Imad Shureiqi
Journal:  Cancer Metastasis Rev       Date:  2011-12       Impact factor: 9.264

3.  Thiazolidinedione use and ulcerative colitis-related flares: an exploratory analysis of administrative data.

Authors:  Jennifer L Lund; Til Stürmer; Carol Q Porter; Robert S Sandler; Michael D Kappelman
Journal:  Inflamm Bowel Dis       Date:  2011-03       Impact factor: 5.325

4.  Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon.

Authors:  Laurent Peyrin-Biroulet; Julia Beisner; Guoxing Wang; Sabine Nuding; Sajit Thottathil Oommen; Denise Kelly; Erika Parmentier-Decrucq; Rodrigue Dessein; Emilie Merour; Philipe Chavatte; Teddy Grandjean; Aude Bressenot; Pierre Desreumaux; Jean-Frédéric Colombel; Béatrice Desvergne; Eduard F Stange; Jan Wehkamp; Mathias Chamaillard
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-26       Impact factor: 11.205

Review 5.  Emerging actions of the nuclear receptor LRH-1 in the gut.

Authors:  Pablo J Fernandez-Marcos; Johan Auwerx; Kristina Schoonjans
Journal:  Biochim Biophys Acta       Date:  2010-12-29

6.  Peroxisome proliferator-activated receptor-γ is downregulated in ulcerative colitis and is involved in experimental colitis-associated neoplasia.

Authors:  Xiaotan Dou; Junhua Xiao; Ziliang Jin; Ping Zheng
Journal:  Oncol Lett       Date:  2015-06-19       Impact factor: 2.967

7.  Enterococcus faecalis from newborn babies regulate endogenous PPARgamma activity and IL-10 levels in colonic epithelial cells.

Authors:  Alexandra Are; Linda Aronsson; Shugui Wang; Gediminas Greicius; Yuan Kun Lee; Jan-Ake Gustafsson; Sven Pettersson; Velmurugesan Arulampalam
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-30       Impact factor: 11.205

Review 8.  Immunopathogenesis of inflammatory bowel disease.

Authors:  David Q Shih; Stephan R Targan
Journal:  World J Gastroenterol       Date:  2008-01-21       Impact factor: 5.742

9.  Isotretinoin use and the risk of inflammatory bowel disease: a population-based cohort study.

Authors:  Raed O Alhusayen; David N Juurlink; Muhammad M Mamdani; Richard L Morrow; Neil H Shear; Colin R Dormuth
Journal:  J Invest Dermatol       Date:  2012-10-25       Impact factor: 8.551

10.  Usefulness of salicylate and thiopurine coprescription in steroid-dependent ulcerative colitis and withdrawal strategies.

Authors:  Fernando Bermejo; Javier P Gisbert
Journal:  Ther Adv Chronic Dis       Date:  2010-05       Impact factor: 5.091
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