Literature DB >> 11472139

Structural characterization of a pentadienyl radical intermediate formed during catalysis by prostaglandin H synthase-2.

S Peng, N M Okeley, A L Tsai, G Wu, R J Kulmacz, W A van der Donk.   

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Year:  2001        PMID： 11472139     DOI： 10.1021/ja015599x

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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  10 in total

1.  Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2.

Authors:  Ah-lim Tsai; Gang Wu; Corina E Rogge; Jian-Ming Lü; Sheng Peng; Wilfred A van der Donk; Graham Palmer; Gary J Gerfen; Richard J Kulmacz
Journal:  J Inorg Biochem       Date:  2010-11-27       Impact factor: 4.155

Review 2.  Rings, radicals, and regeneration: the early years of a bioorganic laboratory.

Authors:  Wilfred A van der Donk
Journal:  J Org Chem       Date:  2006-12-22       Impact factor: 4.354

3.  Synthesis of 7-thiaarachidonic acid as a mechanistic probe of prostaglandin H synthase-2.

Authors:  Chris M McGinley; Cyril Jacquot; Wilfred A van der Donk
Journal:  Bioorg Med Chem Lett       Date:  2007-04-27       Impact factor: 2.823

4.  Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases.

Authors:  Cyril Jacquot; Aaron T Wecksler; Chris M McGinley; Erika N Segraves; Theodore R Holman; Wilfred A van der Donk
Journal:  Biochemistry       Date:  2008-06-12       Impact factor: 3.162

5.  Cyclooxygenase reaction mechanism of PGHS--evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping.

Authors:  Jian-Ming Lü; Corina E Rogge; Gang Wu; Richard J Kulmacz; Wilfred A van der Donk; Ah-lim Tsai
Journal:  J Inorg Biochem       Date:  2011-03       Impact factor: 4.155

6.  Synthesis of site-specifically deuterated arachidonic acid derivatives containing a remote tritium radiolabel.

Authors:  Chris M McGinley; Wilfred A van der Donk
Journal:  J Labelled Comp Radiopharm       Date:  2006-05-17       Impact factor: 1.921

7.  Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects.

Authors:  Gang Wu; Jian-Ming Lü; Wilfred A van der Donk; Richard J Kulmacz; Ah-lim Tsai
Journal:  J Inorg Biochem       Date:  2011-03       Impact factor: 4.155

8.  Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1.

Authors:  Cyril Jacquot; Sheng Peng; Wilfred A van der Donk
Journal:  Bioorg Med Chem Lett       Date:  2008-08-31       Impact factor: 2.823

9.  Molecular dynamics simulations of arachidonic acid complexes with COX-1 and COX-2: insights into equilibrium behavior.

Authors:  Kristina E Furse; Derek A Pratt; Ned A Porter; Terry P Lybrand
Journal:  Biochemistry       Date:  2006-03-14       Impact factor: 3.162

10.  Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity.

Authors:  Kristina E Furse; Derek A Pratt; Claus Schneider; Alan R Brash; Ned A Porter; Terry P Lybrand
Journal:  Biochemistry       Date:  2006-03-14       Impact factor: 3.162
  10 in total

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