Literature DB >> 11469113

Review of statistical methods for QTL mapping in experimental crosses.

K W Broman1.   

Abstract

Identification of quantitative trait loci (QTLs) in experimental animals is critical for understanding the biochemical bases of complex traits, and thus for the identification of drug targets. The author reviews the basic statistical methods for mapping QTLs in experimental crosses and comments on a number of the statistical issues to consider in the application of these methods.

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Year:  2001        PMID： 11469113

Source DB:  PubMed          Journal:  Lab Anim (NY)        ISSN： 0093-7355            Impact factor:   12.625


  48 in total

1.  Gene-expression profiling of experimental autoimmune encephalomyelitis.

Authors:  Eilhard Mix; Jens Pahnke; Saleh M Ibrahim
Journal:  Neurochem Res       Date:  2002-10       Impact factor: 3.996

2.  Functional mapping of quantitative trait loci underlying the character process: a theoretical framework.

Authors:  Chang-Xing Ma; George Casella; Rongling Wu
Journal:  Genetics       Date:  2002-08       Impact factor: 4.562

Review 3.  Genetic sources of individual differences in the cerebellum.

Authors:  David C Airey; Lu Lu; Siming Shou; Robert W Williams
Journal:  Cerebellum       Date:  2002-12       Impact factor: 3.847

4.  WebQTL: web-based complex trait analysis.

Authors:  Jintao Wang; Robert W Williams; Kenneth F Manly
Journal:  Neuroinformatics       Date:  2003

5.  Genetic architecture of voluntary exercise in an advanced intercross line of mice.

Authors:  Scott A Kelly; Derrick L Nehrenberg; Jeremy L Peirce; Kunjie Hua; Brian M Steffy; Tim Wiltshire; Fernando Pardo-Manuel de Villena; Theodore Garland; Daniel Pomp
Journal:  Physiol Genomics       Date:  2010-04-13       Impact factor: 3.107

6.  Quantitative trait loci analysis of tail tendon break time in mice of C57BL/6J and DBA/2J lineage.

Authors:  Lauren B Sloane; Joseph T Stout; David J Vandenbergh; George P Vogler; Glenn S Gerhard; Gerald E McClearn
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-11-03       Impact factor: 6.053

7.  The Dissection of Expression Quantitative Trait Locus Hotspots.

Authors:  Jianan Tian; Mark P Keller; Aimee Teo Broman; Christina Kendziorski; Brian S Yandell; Alan D Attie; Karl W Broman
Journal:  Genetics       Date:  2016-02-02       Impact factor: 4.562

8.  Multiple imputation of missing phenotype data for QTL mapping.

Authors:  Jennifer F Bobb; Daniel O Scharfstein; Michael J Daniels; Francis S Collins; Samir Kelada
Journal:  Stat Appl Genet Mol Biol       Date:  2011

9.  Dissection of floral pollination syndromes in Petunia.

Authors:  Jeroen Stuurman; Maria Elena Hoballah; Larissa Broger; James Moore; Christopher Basten; Cris Kuhlemeier
Journal:  Genetics       Date:  2004-11       Impact factor: 4.562

10.  An efficient resampling method for assessing genome-wide statistical significance in mapping quantitative trait Loci.

Authors:  Fei Zou; Jason P Fine; Jianhua Hu; D Y Lin
Journal:  Genetics       Date:  2004-12       Impact factor: 4.562
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