Literature DB >> 11463685

Relation between insufficient response to antihypertensive treatment and poor compliance with treatment: a prospective case-control study.

R Nuesch1, K Schroeder, T Dieterle, B Martina, E Battegay.   

Abstract

OBJECTIVES: To prospectively compare compliance with treatment in patients with hypertension responsive to treatment versus patients with treatment resistant hypertension.
DESIGN: Prospective case-control study.
SETTING: Outpatient department in a large city hospital in Switzerland, providing primary, secondary, and tertiary care. PARTICIPANTS: 110 consecutive medical outpatients with hypertension and taking stable treatment with at least two antihypertensive drugs for at least four weeks. MAIN OUTCOME MEASURES: Treatment compliance assessed with MEMS devices; blood pressure determined by 12 hour daytime ambulatory monitoring (pressure <135/85 mm Hg in patients aged </=60 years and <155/90 mm Hg in patients aged >60 indicated hypertension responsive to treatment).
RESULTS: Complete data were available for 103 patients, of whom 86 took >/=80% of their prescribed doses ("compliant") and 17 took <80% ("non-compliant"). Of the 49 patients with treatment resistant hypertension, 40 (82%) were compliant, while 46 (85%) of the 54 patients responsive to treatment were compliant.
CONCLUSION: Non-compliance with treatment was not more prevalent in patients with treatment resistant hypertension than in treatment responsive patients.

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Year:  2001        PMID: 11463685      PMCID: PMC34727          DOI: 10.1136/bmj.323.7305.142

Source DB:  PubMed          Journal:  BMJ        ISSN: 0959-8138


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