Review of resistant hypertension.

Despite the prevalence of hypertension, blood pressure (BP) can be controlled with effective therapy in most patients. However, in a small percentage of the hypertensive population, BP remains refractory to therapeutic measures. In such patients who have so-called "resistant" hypertension, proper evaluation and assessment have to be undertaken to improve the BP control. There are some situations or factors that may make hypertension control difficult in some patients. Therefore, it is necessary to identify possible reasons for the loss of BP control and rectify them to achieve normotension. In addition to indicated work-up for secondary causes, aggressive treatment (nonpharmacologic and pharmacologic) of hypertension is required to prevent excessive morbidity and mortality in this special population.