| Literature DB >> 11459665 |
B R Henke1, D H Drewry, S A Jones, E L Stewart, S L Weaver, R W Wiethe.
Abstract
We have prepared a novel series of 2-amino-4,6-diarylpyridines that function as ligands of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta). These compounds bind to both ERalpha and ERbeta with a modest selectivity for the alpha subtype. The most potent of these analogues, compound 19, has a K(i)=20nM at ERalpha. These molecules represent a novel template for designing potentially useful ligands for the estrogen receptor.Entities:
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Year: 2001 PMID： 11459665 DOI： 10.1016/s0960-894x(01)00321-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823