| Literature DB >> 22845666 |
Timothy K Lane1, Brendan R D'Souza, Janis Louie.
Abstract
Diynes and cyanamides undergo an iron-catalyzed [2 + 2 + 2] cycloaddition to form highly substituted 2-aminopyridines in an atom-efficient manner that is both high yielding and regioselective. This system was also used to cyclize two terminal alkynes and a cyanamide to afford a 2,4,6-trisubstituted pyridine product regioselectively.Entities:
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Year: 2012 PMID： 22845666 PMCID： PMC3480319 DOI： 10.1021/jo3012418
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354