| Literature DB >> 11459662 |
J C Bloomer1, H F Boyd, D M Hickey, R J Ife, C A Leach, C H Macphee, K J Milliner, I L Pinto, D A Rawlings, S A Smith, I G Stansfield, S J Stanway, M A Taylor, C J Theobald, C M Whittaker.
Abstract
The lipophilic 1-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, inhibitors of recombinant lipoprotein-associated phospholipase A(2), has been modified to give inhibitors of high potency in human plasma and enhanced physicochemical properties. Phenylpiperazineacetamide derivative 23 shows very promising oral activity.Entities:
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Year: 2001 PMID： 11459662 DOI： 10.1016/s0960-894x(01)00346-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823