Literature DB >> 11454468

Discovery and SAR of org 24598-a selective glycine uptake inhibitor.

A Brown1, I Carlyle, J Clark, W Hamilton, S Gibson, G McGarry, S McEachen, D Rae, S Thorn, G Walker.   

Abstract

The discovery of Org 24598, one of the first potent and selective inhibitors of the glycine transporter is discussed. In vitro structure-activity relationships (SARs) data for interaction of a ligand with this system is discussed.

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Year:  2001        PMID： 11454468     DOI： 10.1016/s0960-894x(01)00355-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

1.  Alterations in brain extracellular dopamine and glycine levels following combined administration of the glycine transporter type-1 inhibitor Org-24461 and risperidone.

Authors:  Katalin Nagy; Bernadett Marko; Gabriella Zsilla; Peter Matyus; Katalin Pallagi; Geza Szabo; Zsolt Juranyi; Jozsef Barkoczy; Gyorgy Levay; Laszlo G Harsing
Journal:  Neurochem Res       Date:  2010-08-20       Impact factor: 3.996

2.  The Concise Guide to PHARMACOLOGY 2013/14: transporters.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

3.  3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors.

Authors:  Emmanuel Pinard; Daniela Alberati; Ruben Alvarez-Sanchez; Virginie Brom; Serge Burner; Holger Fischer; Nicole Hauser; Sabine Kolczewski; Judith Lengyel; Roland Mory; Christian Saladin; Tanja Schulz-Gasch; Henri Stalder
Journal:  ACS Med Chem Lett       Date:  2014-02-04       Impact factor: 4.345

Review 4.  Cognitive enhancers for facilitating drug cue extinction: insights from animal models.

Authors:  Bríd Áine Nic Dhonnchadha; Kathleen M Kantak
Journal:  Pharmacol Biochem Behav       Date:  2011-02-02       Impact factor: 3.533

5.  Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat.

Authors:  Mark D Black; Geoffrey B Varty; Michal Arad; Segev Barak; Amaya De Levie; Denis Boulay; Philippe Pichat; Guy Griebel; Ina Weiner
Journal:  Psychopharmacology (Berl)       Date:  2008-08-16       Impact factor: 4.530

6.  Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord.

Authors:  Amyaouch Bradaïa; Rémy Schlichter; Jérôme Trouslard
Journal:  J Physiol       Date:  2004-07-02       Impact factor: 5.182

7.  The time course of transmitter at glycinergic synapses onto motoneurons.

Authors:  Marco Beato
Journal:  J Neurosci       Date:  2008-07-16       Impact factor: 6.167

Review 8.  Recent advances in the development of novel pharmacological agents for the treatment of cognitive impairments in schizophrenia.

Authors:  Robert W Buchanan; Robert Freedman; Daniel C Javitt; Anissa Abi-Dargham; Jeffrey A Lieberman
Journal:  Schizophr Bull       Date:  2007-07-19       Impact factor: 9.306

9.  The glycine neurotransmitter transporter GLYT1 is an organic osmolyte transporter regulating cell volume in cleavage-stage embryos.

Authors:  Candace L Steeves; Mary-Anne Hammer; Glenn B Walker; Duncan Rae; Nicolas A Stewart; Jay M Baltz
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-13       Impact factor: 11.205

10.  Glycine transporter-1 inhibition preceding extinction training inhibits reacquisition of cocaine seeking.

Authors:  Cindy Achat-Mendes; Bríd Á Nic Dhonnchadha; Donna M Platt; Kathleen M Kantak; Roger D Spealman
Journal:  Neuropsychopharmacology       Date:  2012-09-05       Impact factor: 7.853
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