| Literature DB >> 11454305 |
Abstract
Related individuals are identical by descent (IBD) at a genetic locus if they share the same DNA material from a common ancestor. Continuous gamete IBD data consist of the lengths of (in order) IBD and non-IBD regions along the genomes for gametes segregating from two related individuals and can be used to distinguish different relationships. Under the assumption that the crossovers follow a Poisson process, we show that the exact calculation of the likelihood of a particular relationship for a given gamete IBD datum is tractable. Greatgrandparent--greatgrandchild and cousin relationships are used as examples to illustrate our methods.Mesh:
Year: 2001 PMID: 11454305 DOI: 10.1089/106652701300312940
Source DB: PubMed Journal: J Comput Biol ISSN: 1066-5277 Impact factor: 1.479