Literature DB >> 11454305

On relationship inference using gamete identity by descent data.

H Zhao1, F Liang.   

Abstract

Related individuals are identical by descent (IBD) at a genetic locus if they share the same DNA material from a common ancestor. Continuous gamete IBD data consist of the lengths of (in order) IBD and non-IBD regions along the genomes for gametes segregating from two related individuals and can be used to distinguish different relationships. Under the assumption that the crossovers follow a Poisson process, we show that the exact calculation of the likelihood of a particular relationship for a given gamete IBD datum is tractable. Greatgrandparent--greatgrandchild and cousin relationships are used as examples to illustrate our methods.

Mesh:

Year:  2001        PMID: 11454305     DOI: 10.1089/106652701300312940

Source DB:  PubMed          Journal:  J Comput Biol        ISSN: 1066-5277            Impact factor:   1.479


  3 in total

1.  Improved inference of relationship for pairs of individuals.

Authors:  M P Epstein; W L Duren; M Boehnke
Journal:  Am J Hum Genet       Date:  2000-10-13       Impact factor: 11.025

Review 2.  The estimation of genetic relationships using molecular markers and their efficiency in estimating heritability in natural populations.

Authors:  Stuart C Thomas
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2005-07-29       Impact factor: 6.237

3.  Statistics on continuous IBD data: exact distribution evaluation for a pair of full(half)-sibs and a pair of a (great-) grandchild with a (great-) grandparent.

Authors:  Valeri T Stefanov
Journal:  BMC Genet       Date:  2002-05-07       Impact factor: 2.797

  3 in total

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