Literature DB >> 11452115

Regulation of the immune response by antigen.

R M Zinkernagel1, H Hengartner.   

Abstract

How, why, and when specific T and B lymphocytes respond against infection follow explicit rules, but how this can be assessed experimentally depends crucially on the methodology used. In this Viewpoint, we discuss the parameters of receptor specificity and antigen that determine whether an immune response can be accurately measured against model antigens and how this relates to protection against a given pathogen. We suggest that antigen structure, localization, dose, and time during which antigen is available are all decisive factors in regulating an immune response.

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Year:  2001        PMID： 11452115     DOI： 10.1126/science.1063005

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  72 in total

Review 1.  Naive and memory B cells in T-cell-dependent and T-independent responses.

Authors:  R H Zubler
Journal:  Springer Semin Immunopathol       Date:  2001-12

Review 2.  Mucosal immunity: overcoming the barrier for induction of proximal responses.

Authors:  Brent S McKenzie; Jamie L Brady; Andrew M Lew
Journal:  Immunol Res       Date:  2004       Impact factor: 2.829

3.  B lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions.

Authors:  J Voswinkel; A Mueller; J A Kraemer; P Lamprecht; K Herlyn; K Holl-Ulrich; A C Feller; S Pitann; A Gause; W L Gross
Journal:  Ann Rheum Dis       Date:  2005-11-16       Impact factor: 19.103

4.  Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.

Authors:  Valéria R A Pereira; Virginia M B Lorena; Mineo Nakazawa; Carlos F Luna; Edimilson D Silva; Antonio G P Ferreira; Marco Aurélio Krieger; Samuel Goldenberg; Milena B P Soares; Eridan M Coutinho; Rodrigo Correa-Oliveira; Yara M Gomes
Journal:  Parasitol Res       Date:  2005-04-27       Impact factor: 2.289

Review 5.  Off balance: T-cells in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides.

Authors:  P Lamprecht
Journal:  Clin Exp Immunol       Date:  2005-08       Impact factor: 4.330

Review 6.  Transplant tolerance: models, concepts and facts.

Authors:  Nicola J Monk; Roseanna E G Hargreaves; Elizabeth Simpson; Julian P Dyson; Stipo Jurcevic
Journal:  J Mol Med (Berl)       Date:  2006-02-25       Impact factor: 4.599

7.  Sculpting the immunological response to dengue fever by polytopic vaccination.

Authors:  Hao Zhou; Michael W Deem
Journal:  Vaccine       Date:  2005-12-28       Impact factor: 3.641

8.  Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse.

Authors:  Nadira Durakovic; Vedran Radojcic; Mario Skarica; Karl B Bezak; Jonathan D Powell; Ephraim J Fuchs; Leo Luznik
Journal:  Blood       Date:  2007-01-16       Impact factor: 22.113

9.  A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L.

Authors:  Yan Yan; Leuyen Phan; Fan Yang; Moshe Talpaz; Yu Yang; Zeyu Xiong; Bernard Ng; Nikolai A Timchenko; Catherine J Wu; Jerome Ritz; Hong Wang; Xiao-Feng Yang
Journal:  J Immunol       Date:  2004-01-01       Impact factor: 5.422

10.  Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes.

Authors:  Bernard Ng; Fan Yang; David P Huston; Yan Yan; Yu Yang; Zeyu Xiong; Leif E Peterson; Hong Wang; Xiao-Feng Yang
Journal:  J Allergy Clin Immunol       Date:  2004-12       Impact factor: 10.793
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