| Literature DB >> 11447210 |
I K Santos1, C H Costa, H Krieger, M F Feitosa, D Zurakowski, B Fardin, R B Gomes, D L Weiner, D A Harn, R A Ezekowitz, J E Epstein.
Abstract
Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites. Our findings indicate that MBL can modulate the clinical outcome of infection with L. chagasi and the function of infected macrophages.Entities:
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Year: 2001 PMID: 11447210 PMCID: PMC98624 DOI: 10.1128/IAI.69.8.5212-5215.2001
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441