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Literature DB >> 16899199

Mannan-binding lectin in asthma and allergy.

Savneet Kaur¹, Steffen Thiel, P Usha Sarma, Taruna Madan.

Abstract

Mannan-binding lectin (MBL) is a vital and versatile component of innate immunity. It is present in serum and may bind to a plethora of microbial pathogens and mediate opsonization of these by complement-dependent and/or independent mechanisms. Low-MBL levels in serum, attributed to certain genetic polymorphisms, constitute a major factor predisposing to several infectious diseases. However, recent studies propose that MBL extends beyond its classic role as a first-line host-defense molecule to a modulator of inflammation. In this review, we summarize and explore this potential and a possible novel role of MBL in asthma and allergy.

Entities: Disease Gene

Mesh：

Substances：
Mannose-Binding Lectin

Year: 2006 PMID： 16899199 DOI： 10.1007/s11882-996-0007-6

Source DB: PubMed Journal: Curr Allergy Asthma Rep ISSN： 1529-7322 Impact factor: 4.806

50 in total

Review 1. Collectins: players of the innate immune system.

Authors: J Koenraad van de Wetering; Lambert M G van Golde; Joseph J Batenburg
Journal: Eur J Biochem Date: 2004-04

Review 2. Mannan-binding lectin and its role in innate immunity.

Authors: D C Kilpatrick
Journal: Transfus Med Date: 2002-12 Impact factor: 2.019

Review 3. Role of C5a in inflammatory responses.

Authors: Ren-Feng Guo; Peter A Ward
Journal: Annu Rev Immunol Date: 2005 Impact factor: 28.527

4. Childhood levels of immunoglobulins and mannan-binding lectin in relation to infections and allergy.

Authors: H K Thórarinsdóttir; B R Lúdvíksson; T Víkingsdóttir; M O Leópoldsdóttir; B Ardal; T Jónsson; H Valdimarsson; G J Arason
Journal: Scand J Immunol Date: 2005-05 Impact factor: 3.487

5. Complement activation after oxidative stress: role of the lectin complement pathway.

Authors: C D Collard; A Väkevä; M A Morrissey; A Agah; S A Rollins; W R Reenstra; J A Buras; S Meri; G L Stahl
Journal: Am J Pathol Date: 2000-05 Impact factor: 4.307

6. The development of asthma in children infected with Chlamydia pneumoniae is dependent on the modifying effect of mannose-binding lectin.

Authors: Adrienne Nagy; Gergely T Kozma; Márton Keszei; András Treszl; András Falus; Csaba Szalai
Journal: J Allergy Clin Immunol Date: 2003-10 Impact factor: 10.793

7. Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin.

Authors: Nades Palaniyar; Jeya Nadesalingam; Howard Clark; Michael J Shih; Alister W Dodds; Kenneth B M Reid
Journal: J Biol Chem Date: 2004-05-15 Impact factor: 5.157

Review 8. Recombinant mannan-binding lectin (MBL) for therapy.

Authors: J C Jensenius; P H Jensen; K McGuire; J L Larsen; S Thiel
Journal: Biochem Soc Trans Date: 2003-08 Impact factor: 5.407

9. Lung surfactant proteins A and D can inhibit specific IgE binding to the allergens of Aspergillus fumigatus and block allergen-induced histamine release from human basophils.

Authors: T Madan; U Kishore; A Shah; P Eggleton; P Strong; J Y Wang; S S Aggrawal; P U Sarma; K B Reid
Journal: Clin Exp Immunol Date: 1997-11 Impact factor: 4.330

Review 10. Mannan-binding lectin--a soluble pattern recognition molecule.

Authors: Mihaela Gadjeva; Kazue Takahashi; Steffen Thiel
Journal: Mol Immunol Date: 2004-06 Impact factor: 4.407

4 in total

1. Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk.

Authors: Susan E Olivo-Marston; Ping Yang; Leah E Mechanic; Elise D Bowman; Sharon R Pine; Christopher A Loffredo; Anthony J Alberg; Neil Caporaso; Peter G Shields; Stephen Chanock; Yanhong Wu; Ruoxiang Jiang; Julie Cunningham; Jin Jen; Curtis C Harris
Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-12 Impact factor: 4.254