Literature DB >> 11445811

The use of alteplase to restore patency of central venous lines in pediatric patients: a cohort study.

M Choi1, M P Massicotte, V Marzinotto, A K Chan, J L Holmes, M Andrew.   

Abstract

We evaluated the efficacy and safety of alteplase to restore central venous line (CVL) patency in a consecutive cohort study. A uniform, weight-dependent protocol for alteplase administration was established prospectively. For children < or =10 kg, a dose of 0.5 mg was used; for children >10 kg, doses of 1 to 2 mg were used. The alteplase remained instilled for 1 to 4 hours or overnight. Retrospective data accrual found that 25 children received alteplase for a total of 34 courses; 29 (85%) of the 34 courses of alteplase completely restored CVL patency. Alteplase appears to be a safe and effective thrombolytic agent for CVL patency restoration in children.

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Year:  2001        PMID： 11445811     DOI： 10.1067/mpd.2001.115019

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  6 in total

1.  Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Authors:  Paul Monagle; Anthony K C Chan; Neil A Goldenberg; Rebecca N Ichord; Janna M Journeycake; Ulrike Nowak-Göttl; Sara K Vesely
Journal:  Chest       Date:  2012-02       Impact factor: 9.410

Review 2.  Thrombolytic therapy for central venous catheter occlusion.

Authors:  Jacquelyn L Baskin; Ulrike Reiss; Judith A Wilimas; Monika L Metzger; Raul C Ribeiro; Ching-Hon Pui; Scott C Howard
Journal:  Haematologica       Date:  2011-12-16       Impact factor: 9.941

3.  Recombinant tissue plasminogen activator infusion for hemodialysis catheter clearance.

Authors:  Oluwatoyin F Bamgbola; Marcela del Rio; Frederick J Kaskel; Joseph T Flynn
Journal:  Pediatr Nephrol       Date:  2005-04-21       Impact factor: 3.714

Review 4.  Interventions for restoring patency of occluded central venous catheter lumens.

Authors:  Clare van Miert; Rebecca Hill; Leanne Jones
Journal:  Cochrane Database Syst Rev       Date:  2012-04-18

Review 5.  Management of occlusion and thrombosis associated with long-term indwelling central venous catheters.

Authors:  Jacquelyn L Baskin; Ching-Hon Pui; Ulrike Reiss; Judith A Wilimas; Monika L Metzger; Raul C Ribeiro; Scott C Howard
Journal:  Lancet       Date:  2009-07-11       Impact factor: 79.321

6.  [Obstruction of peripherally inserted central catheters in newborns: prevention is the best intervention].

Authors:  Mavilde Luz Gonçalves Pedreira
Journal:  Rev Paul Pediatr       Date:  2015-06-11
  6 in total

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