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Literature DB >> 11445444

Fatty acid transport proteins: a current view of a growing family.

A Stahl¹, R E Gimeno, L A Tartaglia, H F Lodish.

Abstract

Long-chain fatty acids (LCFAs) are a major caloric component of our diet and are key metabolites for energy generation and storage. Physiological uptake of LCFAs across cell membranes is a saturable and competable process occurring at low concentrations, indicative of protein-mediated transport. Fatty acid transport proteins are a family of transmembrane proteins that enhance LCFA uptake and are produced in all fatty acid-utilizing tissues. Here, we review our current understanding of the function, expression patterns and regulation and subcellular localization of this interesting family of proteins.

Entities: Chemical

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Year: 2001 PMID： 11445444 DOI： 10.1016/s1043-2760(01)00427-1

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

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Cited

74 in total

1. FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase.

Authors: Alaric Falcon; Holger Doege; Amy Fluitt; Bernice Tsang; Nicki Watson; Mark A Kay; Andreas Stahl
Journal: Am J Physiol Endocrinol Metab Date: 2010-06-08 Impact factor: 4.310

2. Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5.

Authors: Wei Zhou; Peter Madrid; Amy Fluitt; Andreas Stahl; Xinmin Simon Xie
Journal: J Biomol Screen Date: 2010-05-06

3. Real-time microscopic assessment of fatty acid uptake kinetics in the human term placenta.

Authors: Kevin S Kolahi; Amy M Valent; Kent L Thornburg
Journal: Placenta Date: 2018-07-31 Impact factor: 3.481

4. Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases.

Authors: Nicolas G Bazan; Miguel F Molina; William C Gordon
Journal: Annu Rev Nutr Date: 2011-08-21 Impact factor: 11.848

Review 5. Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome.

Authors: Paul D Berk
Journal: Hepatology Date: 2008-11 Impact factor: 17.425

10. Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice.

Authors: Fengxia Ge; Shengli Zhou; Chunguang Hu; Harrison Lobdell; Paul D Berk
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2010-07-01 Impact factor: 4.052

Fatty acid transport proteins: a current view of a growing family.

1. FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase.

2. Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5.

3. Real-time microscopic assessment of fatty acid uptake kinetics in the human term placenta.

4. Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases.

Review 5. Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome.

6. Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts.

7. FATP1 silence inhibits the differentiation and induces the apoptosis in chicken preadipocytes.

Review 8. Genetic engineering of microorganisms for biodiesel production.

Review 9. Dysregulated fatty acid metabolism in hepatocellular carcinoma.

10. Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice.