| Literature DB >> 30191046 |
Mingda Wang1,1, Jun Han1,1, Hao Xing1,1, Han Zhang1,1, Zhenli Li1,1, Lei Liang1,2,1,2, Chao Li1,1, Shuyang Dai1,1, Mengchao Wu1,1, Feng Shen1,1, Tian Yang1,1.
Abstract
Hepatocellular carcinoma (HCC) is one of the most frequent and deadly malignancies worldwide. Studies are urgently needed on its molecular pathogenesis and biological characteristics. Dysregulation of fatty acid (FA) metabolism, in which aberrant activation of oncogenic signaling pathways alters the expression and activity of lipid-metabolizing enzymes, is an emerging hallmark of cancer cells, and it may be involved in HCC development and progression. The current review summarizes what is known about dysregulated FA metabolism in HCC and pathways through which this dysregulation may regulate HCC survival and growth. Our understanding of dysregulated FA metabolism and associated signaling pathways may contribute to the development of novel and efficient antitumor approaches for patients with HCC.Entities:
Keywords: carcinogenesis; fatty acid oxidation; fatty acid synthesis; fatty acid uptake; hepatitis C virus; hepatocellular carcinoma; lipolytic pathway; nonalcoholic fatty liver disease
Year: 2017 PMID： 30191046 PMCID： PMC6095185 DOI： 10.2217/hep-2016-0012
Source DB: PubMed Journal: Hepat Oncol ISSN： 2045-0923