Literature DB >> 11443233

Small is mighty: EmrE, a multidrug transporter as an experimental paradigm.

S Schuldiner1, D Granot, S S Mordoch, S Ninio, D Rotem, M Soskin, C G Tate, H Yerushalmi.   

Abstract

EmrE is a multidrug transporter from Escherichia coli that functions as a homooligomer and is unique in its small size. In each monomer there are four tightly packed transmembrane segments and one membrane-embedded charged residue. This residue provides the basis for the coupling mechanism as part of a binding site "time shared" by substrates and protons.

Entities:  

Mesh:

Substances:

Year:  2001        PMID: 11443233     DOI: 10.1152/physiologyonline.2001.16.3.130

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN: 0886-1714


  24 in total

1.  In vitro synthesis of fully functional EmrE, a multidrug transporter, and study of its oligomeric state.

Authors:  Yael Elbaz; Sonia Steiner-Mordoch; Tsafi Danieli; Shimon Schuldiner
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-30       Impact factor: 11.205

2.  Three-dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer.

Authors:  Iban Ubarretxena-Belandia; Joyce M Baldwin; Shimon Schuldiner; Christopher G Tate
Journal:  EMBO J       Date:  2003-12-01       Impact factor: 11.598

Review 3.  Structure and function of efflux pumps that confer resistance to drugs.

Authors:  M Ines Borges-Walmsley; Kenneth S McKeegan; Adrian R Walmsley
Journal:  Biochem J       Date:  2003-12-01       Impact factor: 3.857

4.  A structural model of EmrE, a multi-drug transporter from Escherichia coli.

Authors:  Kay-Eberhard Gottschalk; Misha Soskine; Shimon Schuldiner; Horst Kessler
Journal:  Biophys J       Date:  2004-06       Impact factor: 4.033

5.  Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli.

Authors:  Che Ma; Geoffrey Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-17       Impact factor: 11.205

6.  Structure, dynamics, and substrate-induced conformational changes of the multidrug transporter EmrE in liposomes.

Authors:  Sepan T Amadi; Hanane A Koteiche; Sanjay Mishra; Hassane S McHaourab
Journal:  J Biol Chem       Date:  2010-06-15       Impact factor: 5.157

Review 7.  Vacuuming the periplasm.

Authors:  Olga Lomovskaya; Maxim Totrov
Journal:  J Bacteriol       Date:  2005-03       Impact factor: 3.490

Review 8.  Multidrug resistance in bacteria.

Authors:  Hiroshi Nikaido
Journal:  Annu Rev Biochem       Date:  2009       Impact factor: 23.643

9.  The fast release of sticky protons: kinetics of substrate binding and proton release in a multidrug transporter.

Authors:  Yoav Adam; Naama Tayer; Dvir Rotem; Gideon Schreiber; Shimon Schuldiner
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-02       Impact factor: 11.205

10.  Crosslinking of membrane-embedded cysteines reveals contact points in the EmrE oligomer.

Authors:  Misha Soskine; Sonia Steiner-Mordoch; Shimon Schuldiner
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-09       Impact factor: 11.205

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.