BACKGROUND: A relationship between bone turnover and the vitamin D receptor (VDR) genotype is reported in Australian subjects of UK-Irish descent. There is conflicting evidence of linkage between the VDR genotype and differences in bone mineral density. No such study has been carried out on a resident Irish population. AIMS: This study examined the relationship between serum osteocalcin (a marker of bone turnover) and VDR genotype in Irish adults. METHODS: One hundred and eighteen healthy Irish adults aged between 19 and 67 were recruited and had two fasting blood samples taken. One sample was analysed for osteocalcin by enzyme immunoassay. The other was used to isolate genomic DNA and determine VDR genotype. RESULTS: Tt was the most prevalent VDR genotype (53%) and tt (15%) the least prevalent in this group of healthy Irish adults. The tt VDR genotype was associated with significantly higher levels of serum osteocalcin (29% and 40%) than the Tt or TT VDR genotypes. CONCLUSIONS: These findings suggest that healthy Irish adults with the tt VDR genotype have higher rates of bone turnover than those with Tt or TTVDR genotypes. They may have a higher risk of low bone mineral density and osteoporosis in later life.
BACKGROUND: A relationship between bone turnover and the vitamin D receptor (VDR) genotype is reported in Australian subjects of UK-Irish descent. There is conflicting evidence of linkage between the VDR genotype and differences in bone mineral density. No such study has been carried out on a resident Irish population. AIMS: This study examined the relationship between serum osteocalcin (a marker of bone turnover) and VDR genotype in Irish adults. METHODS: One hundred and eighteen healthy Irish adults aged between 19 and 67 were recruited and had two fasting blood samples taken. One sample was analysed for osteocalcin by enzyme immunoassay. The other was used to isolate genomic DNA and determine VDR genotype. RESULTS: Tt was the most prevalent VDR genotype (53%) and tt (15%) the least prevalent in this group of healthy Irish adults. The tt VDR genotype was associated with significantly higher levels of serum osteocalcin (29% and 40%) than the Tt or TT VDR genotypes. CONCLUSIONS: These findings suggest that healthy Irish adults with the tt VDR genotype have higher rates of bone turnover than those with Tt or TTVDR genotypes. They may have a higher risk of low bone mineral density and osteoporosis in later life.
Authors: F Rauch; A Radermacher; A Danz; U Schiedermaier; A Golücke; D Michalk; E Schönau Journal: Exp Clin Endocrinol Diabetes Date: 1997 Impact factor: 2.949
Authors: A Tokita; P J Kelly; T V Nguyen; J C Qi; N A Morrison; L Risteli; J Risteli; P N Sambrook; J A Eisman Journal: J Clin Endocrinol Metab Date: 1994-06 Impact factor: 5.958
Authors: J M Wishart; M Horowitz; A G Need; F Scopacasa; H A Morris; P M Clifton; B E Nordin Journal: Am J Clin Nutr Date: 1997-03 Impact factor: 7.045
Authors: T D Spector; R W Keen; N K Arden; N A Morrison; P J Major; T V Nguyen; P J Kelly; J R Baker; P N Sambrook; J S Lanchbury Journal: BMJ Date: 1995-05-27