Literature DB >> 11440152

Pentalenolactone I and hygromycin A, immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus.

M Uyeda1, M Mizukami, K Yokomizo, K Suzuki.   

Abstract

Immunosuppressants isolated from Streptomyces filipinensis and S. hygroscopicus were identified with pentalenolactone I and hygromycin A, respectively. The compounds as well as cyclosporin A showed immunosuppressant activity in the mixed lymphocyte reaction, and pentalenolactone I and cyclosporin A suppressed IL-2 production, however, hygromycin A did not. Hygromycin A may have immunosuppressant activity by a different mechanism from pentalenolactone I, cyclosporin A and tacrolimus.

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Year:  2001        PMID： 11440152     DOI： 10.1271/bbb.65.1252

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  7 in total

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Authors:  Essaid Ait Barka; Parul Vatsa; Lisa Sanchez; Nathalie Gaveau-Vaillant; Cedric Jacquard; Jan P Meier-Kolthoff; Hans-Peter Klenk; Christophe Clément; Yder Ouhdouch; Gilles P van Wezel
Journal:  Microbiol Mol Biol Rev       Date:  2015-11-25       Impact factor: 11.056

2.  Bioactive compounds from marine actinomycetes.

Authors:  Renu Solanki; Monisha Khanna; Rup Lal
Journal:  Indian J Microbiol       Date:  2009-01-08       Impact factor: 2.461

3.  Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Authors:  Yury S Polikanov; Agata L Starosta; Manuel F Juette; Roger B Altman; Daniel S Terry; Wanli Lu; Benjamin J Burnett; George Dinos; Kevin A Reynolds; Scott C Blanchard; Thomas A Steitz; Daniel N Wilson
Journal:  Mol Cell       Date:  2015-05-28       Impact factor: 17.970

4.  Biosynthetic origin of hygromycin A.

Authors:  El-Sayed E Habib; J Neel Scarsdale; Kevin A Reynolds
Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191

Review 5.  Bacterial terpenome.

Authors:  Jeffrey D Rudolf; Tyler A Alsup; Baofu Xu; Zining Li
Journal:  Nat Prod Rep       Date:  2021-05-26       Impact factor: 15.111

6.  Comparative Genomic Insights into Secondary Metabolism Biosynthetic Gene Cluster Distributions of Marine Streptomyces.

Authors:  Lin Xu; Kai-Xiong Ye; Wen-Hua Dai; Cong Sun; Lian-Hua Xu; Bing-Nan Han
Journal:  Mar Drugs       Date:  2019-08-26       Impact factor: 5.118

7.  Metabolomic study of marine Streptomyces sp.: Secondary metabolites and the production of potential anticancer compounds.

Authors:  Marcelo M P Tangerina; Luciana Costa Furtado; Vida M B Leite; Anelize Bauermeister; Karen Velasco-Alzate; Paula C Jimenez; Leandro M Garrido; Gabriel Padilla; Norberto P Lopes; Leticia V Costa-Lotufo; Marcelo J Pena Ferreira
Journal:  PLoS One       Date:  2020-12-21       Impact factor: 3.240
  7 in total

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