Literature DB >> 11440138

Aurantiamide acetate, a selective cathepsin inhibitor, produced by Aspergillus penicilloides.

K Isshiki1, Y Asai, S Tanaka, M Nishio, T Uchida, T Okuda, S Komatsubara, N Sakurai.   

Abstract

Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L (3.4.22.15) and B (3.4.22.1) with IC50 of 12 microM and 49 microM, respectively. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.

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Year:  2001        PMID： 11440138     DOI： 10.1271/bbb.65.1195

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  6 in total

1.  Phylogeny of xerophilic aspergilli (subgenus Aspergillus) and taxonomic revision of section Restricti.

Authors:  F Sklenář; Ž Jurjević; P Zalar; J C Frisvad; C M Visagie; M Kolařík; J Houbraken; A J Chen; N Yilmaz; K A Seifert; M Coton; F Déniel; N Gunde-Cimerman; R A Samson; S W Peterson; V Hubka
Journal:  Stud Mycol       Date:  2017-09-27       Impact factor: 16.097

2.  Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists.

Authors:  Margherita Mastromarino; Liliya N Kirpotina; Igor A Schepetkin; Mark T Quinn; Enza Lacivita; Marcello Leopoldo
Journal:  Medchemcomm       Date:  2019-10-07       Impact factor: 3.597

3.  Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic flux.

Authors:  Yi Yang; Li-hui Zhang; Bing-xian Yang; Jin-kui Tian; Lin Zhang
Journal:  J Cell Mol Med       Date:  2015-02-20       Impact factor: 5.310

4.  Chemical constituents from stem bark and roots of Clausena anisata.

Authors:  Jules Lobe Songue; Etienne Dongo; Theophile Ngando Mpondo; Robert L White
Journal:  Molecules       Date:  2012-11-20       Impact factor: 4.411

5.  The Microbiome and Metabolites in Fermented Pu-erh Tea as Revealed by High-Throughput Sequencing and Quantitative Multiplex Metabolite Analysis.

Authors:  Yongjie Zhang; Ida Skaar; Michael Sulyok; Xingzhong Liu; Mingyong Rao; John W Taylor
Journal:  PLoS One       Date:  2016-06-23       Impact factor: 3.240

6.  Identification of Potential Dipeptidyl Peptidase (DPP)-IV Inhibitors among Moringa oleifera Phytochemicals by Virtual Screening, Molecular Docking Analysis, ADME/T-Based Prediction, and In Vitro Analyses.

Authors:  Yang Yang; Chong-Yin Shi; Jing Xie; Jia-He Dai; Shui-Lian He; Yang Tian
Journal:  Molecules       Date:  2020-01-02       Impact factor: 4.411
  6 in total

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