| Literature DB >> 11435694 |
Z Zhou1, K Ying, J Dai, R Tang, W Wang, Y Huang, W Zhao, Y Xie, Y Mao.
Abstract
During the large-scale sequencing analysis of a human fetal brain cDNA library, we isolated two cDNA clones encoding two novel proteins, which show 52% and 72% identity to the cyclophilin isoform 10 of C. elegans, respectively. Sequence analysis revealed these two cDNA clones are two different splicing variants of a novel cyclophilin-like gene (PPIL3). The PPIL3 gene was identified on a completely sequenced BAC (GenBank accession AC005037) from chromosome 2q33 between STS markers stSG2762 (proximal) and SHGC-3074 (distal), oriented toward the telomere. The PPIL3 gene consisted of eight exons spanning more than 18 kb of genomic DNA. RT-PCR analysis indicated that PPIL3 was ubiquitously expressed in adult human tissues. Copyright 2001 S. Karger AG, Basel.Entities:
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Year: 2001 PMID： 11435694 DOI： 10.1159/000056909
Source DB: PubMed Journal: Cytogenet Cell Genet ISSN： 0301-0171