Literature DB >> 11432838

An upstream repressor element plays a role in Igf2 imprinting.

S Eden1, M Constancia, T Hashimshony, W Dean, B Goldstein, A C Johnson, I Keshet, W Reik, H Cedar.   

Abstract

The imprinted Igf2 gene is associated with a small upstream region that is differentially methylated on the active paternal allele. We have identified a repressor element within this sequence and shown that repression is probably mediated through a trans- acting factor, GCF2. DNA methylation of this site abrogates both protein binding and repressor activity. Targeting experiments demonstrate that this element plays a role in the repression of the maternal Igf2 gene in vivo.

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Year:  2001        PMID： 11432838      PMCID： PMC125515          DOI： 10.1093/emboj/20.13.3518

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  38 in total

1.  A silencer element identified in Drosophila is required for imprinting of H19 reporter transgenes in mice.

Authors:  J D Brenton; R A Drewell; S Viville; K J Hilton; S C Barton; J F Ainscough; M A Surani
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

2.  Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19.

Authors:  M Constância; W Dean; S Lopes; T Moore; G Kelsey; W Reik
Journal:  Nat Genet       Date:  2000-10       Impact factor: 38.330

3.  DNA methylation models histone acetylation.

Authors:  S Eden; T Hashimshony; I Keshet; H Cedar; A W Thorne
Journal:  Nature       Date:  1998-08-27       Impact factor: 49.962

Review 4.  Imprinting mechanisms.

Authors:  M Constância; B Pickard; G Kelsey; W Reik
Journal:  Genome Res       Date:  1998-09       Impact factor: 9.043

5.  Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex.

Authors:  X Nan; H H Ng; C A Johnson; C D Laherty; B M Turner; R N Eisenman; A Bird
Journal:  Nature       Date:  1998-05-28       Impact factor: 49.962

6.  Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription.

Authors:  P L Jones; G J Veenstra; P A Wade; D Vermaak; S U Kass; N Landsberger; J Strouboulis; A P Wolffe
Journal:  Nat Genet       Date:  1998-06       Impact factor: 38.330

Review 7.  CpG methylation, chromatin structure and gene silencing-a three-way connection.

Authors:  A Razin
Journal:  EMBO J       Date:  1998-09-01       Impact factor: 11.598

8.  Molecular analysis of the GCF gene identifies revisions to the cDNA and amino acid sequences(1).

Authors:  M Takimoto; P Mao; G Wei; H Yamazaki; T Miura; A C Johnson; N Kuzumaki
Journal:  Biochim Biophys Acta       Date:  1999-10-06

9.  GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury.

Authors:  L M Khachigian; F S Santiago; L A Rafty; O L Chan; G J Delbridge; A Bobik; T Collins; A C Johnson
Journal:  Circ Res       Date:  1999-06-11       Impact factor: 17.367

10.  Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor.

Authors:  A L Reed; H Yamazaki; J D Kaufman; Y Rubinstein; B Murphy; A C Johnson
Journal:  J Biol Chem       Date:  1998-08-21       Impact factor: 5.157
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  29 in total

1.  An intragenic methylated region in the imprinted Igf2 gene augments transcription.

Authors:  A Murrell; S Heeson; L Bowden; M Constância; W Dean; G Kelsey; W Reik
Journal:  EMBO Rep       Date:  2001-11-21       Impact factor: 8.807

Review 2.  Imprinting and seed development.

Authors:  Mary Gehring; Yeonhee Choi; Robert L Fischer
Journal:  Plant Cell       Date:  2004-03-09       Impact factor: 11.277

3.  Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.

Authors:  Susan K Murphy; Catherine M Nolan; Zhiqing Huang; Katerina S Kucera; Brad A Freking; Timothy P L Smith; Kreg A Leymaster; Jennifer R Weidman; Randy L Jirtle
Journal:  Genome Res       Date:  2006-01-13       Impact factor: 9.043

Review 4.  DNA methylation and its role in the pathogenesis of diabetes.

Authors:  Amita Bansal; Sara E Pinney
Journal:  Pediatr Diabetes       Date:  2017-05       Impact factor: 4.866

5.  CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region.

Authors:  Li Han; Dong-Hoon Lee; Piroska E Szabó
Journal:  Mol Cell Biol       Date:  2007-11-26       Impact factor: 4.272

6.  A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele.

Authors:  Xinwen Qiu; Thanh H Vu; Qiucheng Lu; Jian Qun Ling; Tao Li; Aiju Hou; Shu Kui Wang; Hui Ling Chen; Ji Fan Hu; Andrew R Hoffman
Journal:  Mol Endocrinol       Date:  2008-03-20

7.  RNA-directed DNA methylation induces transcriptional activation in plants.

Authors:  Kenichi Shibuya; Setsuko Fukushima; Hiroshi Takatsuji
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-21       Impact factor: 11.205

Review 8.  Epigenetics and developmental origins of diabetes: correlation or causation?

Authors:  Amita Bansal; Rebecca A Simmons
Journal:  Am J Physiol Endocrinol Metab       Date:  2018-02-06       Impact factor: 4.310

9.  Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.

Authors:  Xi Li; Qinwei Sun; Xian Li; Demin Cai; Shiyan Sui; Yimin Jia; Haogang Song; Ruqian Zhao
Journal:  Eur J Nutr       Date:  2014-11-20       Impact factor: 5.614

10.  Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.

Authors:  Folami Y Ideraabdullah; Joanne L Thorvaldsen; Jennifer A Myers; Marisa S Bartolomei
Journal:  Hum Mol Genet       Date:  2014-07-02       Impact factor: 6.150
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